RAB25 - RAB25, member RAS oncogene family Gene

Also Known as CATX-8; RAB11C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57111

About RAB25

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,061,160-156,070,504 (from NCBI)

This gene has 5 transcripts (splice variants), 265 orthologues and 68 paralogues. Biased expression in esophagus (RPKM 128.3), skin (RPKM 60.6) and 12 other tissues.

Summary

The protein encoded by this gene is a member of the Ras superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the Other not, have been found for this gene. [provided by RefSeq, Nov 2015]

RAB25 Products (1)

mRNA Protein Name
NM_020387.4 NP_065120.2 ras-related protein Rab-25 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables myosin V binding IPI
IPI: Inferred from physical interaction
24006491 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17925226 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15502842 GOA
involved in positive regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
22613965 GOA
involved in pseudopodium organization IDA
IDA: Inferred from direct assay
17925226 GOA
involved in regulation of vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
22613965 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
17925226 GOA
located in pseudopodium IDA
IDA: Inferred from direct assay
17925226 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB25 Protein Structure

Ras

Ras: Ras family (14 - 173)

  • 0
  • 100
  • 200
  • 213 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-25

RAB25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAB25 P57735 RAB11FIP2 Homo sapiens Q7L804
Validated Y2H
32296183
Intra
RAB25 P57735 MYO5B Homo sapiens Q9ULV0-2
Validated Y2H
32296183
Intra
RAB25 P57735 SH3BP5L Homo sapiens Q7L8J4
Y2H Prey Pooling
32296183
Intra
RAB25 P57735 SH3BP5L Homo sapiens Q7L8J4
Validated Y2H
32296183
Intra
RAB25 P57735 SH3BP5L Homo sapiens Q7L8J4
Y2H Array
32296183
Cross
RAB25 P57735 P08563-PRO_0000041303 Rubella virus P08563-PRO_0000041303
Pull Down
24955142
Cross: Cross-species interaction Intra: Intraspecies interaction

RAB25 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82136 Rab25 Antibody (YA1881) WB Human
HY-P85343 Rab25 Antibody (YA5035) WB Human

Related Diseases

Diseases Alias
Binocular Vision Disease

  • Simultaneous Visual Perception Without Fusion
Corneal Dystrophy, Posterior Polymorphous, 4

  • PPCD4

  • Posterior Polymorphous Corneal Dystrophy 4
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11535 RAB25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19544 Lamtor2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RAB25 VGNC VGNC:45265
Rattus norvegicus RAB25 RGD RGD:1308447
Mus musculus RAB25 MGD MGI:1858203
Bos taurus RAB25 VGNC VGNC:33632
Macaca mulatta RAB25 VGNC VGNC:81525
Felis catus RAB25 VGNC VGNC:97585
Others RAB25 NCBI