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  4. Monoclonal Antibodies Recombinant Antibodies
  5. Rab25 Antibody (YA1881)

Rab25 Antibody (YA1881)

Cat. No.: HY-P82136
User Guide for Antibodies Technical Support

Rab25 Antibody (YA1881) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rab25.

For research use only. We do not sell to patients.

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20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Rab25 Antibody (YA1881) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rab25.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 23 kDa;
Observed band size: 23 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human Rab25 aa1-213/213.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis (PubMed:17925226). Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway (By similarity). Together with MYO5B regulates transcytosis (By similarity)
Subcellular Localization：Cell membrane; Lipid-anchor; Cytoplasmic side; Cytoplasmic vesicle; Cell projection, pseudopodium membrane
Expression：
Tissue_specificity:This gene is expressed only in epithelial cells (PubMed: 15502842) . It is expressed in both ovarian epithelial (NOE) and breast tissue. It is also expressed in ovarian cancer; its expression level is higher than in NOE cells. Expression in ovarian cancer is stage-dependent, with higher expression levels in stage III and IV ovarian cancer than in early-stage ovarian cancer. It is also expressed in breast cancer; its expression level is higher than in normal breast tissue.
Subunit：Interacts (GTP-bound form) with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4 (PubMed:11495908, PubMed:26032412). Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent (PubMed:17925226). Interacts with ITGAV (PubMed:17925226). Associates with the integrin alpha-V/beta-1 heterodimer. Interacts with VPS33B (PubMed:28017832)
Database

Entrez Gene: 57111 Human

SwissProt: P57735 Human

OMIM: 612942 Human

Research Field

Signal Transduction
Synonyms
RAB25; CATX8; Ras-related protein Rab-25; CATX-8
Documentation
User Guide for Antibodies (1077 KB)

Rab25 Antibody (YA1881) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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