Sotolone
Sotolone (Dimethylhydroxyfuranone) is an activator of the human olfactory receptor OR8D1. Sotolone activates the human olfactory receptor OR8D1, with EC50 values of 84.98 μM and 167.2 μM for its S-enantiomer and R-enantiomer, respectively. Sotolone has unique aroma profiles: (R)-sotolone exhibits smoky, burnt, herbal and grassy notes; (S)-sotolone presents sweet, milky, sour and nutty notes. Sotolone also acts as an antifungal agent, showing moderate inhibitory activity against Magnaporthe oryzae in vitro.
For research use only. We do not sell to patients.
- Purity: ≥95.0%
- CAS No.: 28664-35-9
- Formula: C6H8O3
- Molecular Weight:128.13
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Sotolone (200 µg/mL; 2-6 days) exhibits weak to moderate in vitro inhibitory activity against Magnaporthe oryzae BV, Sclerotium rolfsii, and Phytophthora capsici, with IC50 values of 256.0 µg/mL, 333.7 µg/mL, and 279.2 µg/mL respectively, and weaker activity against other tested phytopathogenic fungi[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 28664-35-9
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Appearance Liquid (Density: 1.049 g/cm3)
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Molecular Weight 128.13
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Formula C6H8O3
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Color Colorless to light yellow
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SMILES
O=C1OC(C(=C1O)C)C
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Synonyms
Dimethylhydroxyfuranone
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (780.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.8046 mL | 39.0229 mL | 78.0457 mL | 195.1143 mL |
| 5 mM | 1.5609 mL | 7.8046 mL | 15.6091 mL | 39.0229 mL | |
| 10 mM | 0.7805 mL | 3.9023 mL | 7.8046 mL | 19.5114 mL | |
| 15 mM | 0.5203 mL | 2.6015 mL | 5.2030 mL | 13.0076 mL | |
| 20 mM | 0.3902 mL | 1.9511 mL | 3.9023 mL | 9.7557 mL | |
| 25 mM | 0.3122 mL | 1.5609 mL | 3.1218 mL | 7.8046 mL | |
| 30 mM | 0.2602 mL | 1.3008 mL | 2.6015 mL | 6.5038 mL | |
| 40 mM | 0.1951 mL | 0.9756 mL | 1.9511 mL | 4.8779 mL | |
| 50 mM | 0.1561 mL | 0.7805 mL | 1.5609 mL | 3.9023 mL | |
| 60 mM | 0.1301 mL | 0.6504 mL | 1.3008 mL | 3.2519 mL | |
| 80 mM | 0.0976 mL | 0.4878 mL | 0.9756 mL | 2.4389 mL | |
| 100 mM | 0.0780 mL | 0.3902 mL | 0.7805 mL | 1.9511 mL |
Sotolone Related Classifications
HY-W021008 Related Classifications
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