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Cat. No.: HY-162042

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AMPK activator 14

AMPK activator 14 (compound 32) is an orally active AMPK activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes.

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CAS No.: 1356632-18-2
화학식: C₃₃H₃₄FN₅O₄
분자량:583.65

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

AMPK activator 14 Chemical Structure

CAS No.: 1356632-18-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

AMPK activator 14 (compound 32) is an orally active AMPK activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes^[1].

All AMPK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>20 μM Compound: 32	Cytotoxicity against human A549 cells assessed as reduction in cell growth Cytotoxicity against human A549 cells assessed as reduction in cell growth	[PMID: 38079537]
HepG2	IC₅₀	1.171 μM Compound: 32	Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production	[PMID: 38079537]
NCI-H1299	IC₅₀	>20 μM Compound: 32	Cytotoxicity against human NCI-H1299 cells assessed as reduction in cell growth Cytotoxicity against human NCI-H1299 cells assessed as reduction in cell growth	[PMID: 38079537]

Chemical Information

CAS No. 1356632-18-2
분자량 583.65
화학식 C₃₃H₃₄FN₅O₄
SMILES

COC1=CC=C(C=C1)C(C2CCN(CC2)C(C3=NC=C(C=C3)C(N[C@H]4CCN(CC5=CC=C(C=C5)C#N)C[C@@H]4F)=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shaw SJ, et al. Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators. J Med Chem. 2023;66(24):17086-17104. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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AMPK activator 14

All AMPK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AMPK activator 14 Related Classifications

HY-162042 Related Classifications