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Cat. No.: HY-142820

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B-Raf IN 5

B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC₅₀ of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2648698-30-8
화학식: C₂₃H₁₈ClF₃N₆O₃S₂
분자량:583.01

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

B-Raf IN 5 Chemical Structure

CAS No.: 2648698-30-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Raf Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	2.06 nM Compound: 3b	Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 5 days by MTT assay Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 5 days by MTT assay	[PMID: 34958586]

Chemical Information

CAS No. 2648698-30-8
분자량 583.01
화학식 C₂₃H₁₈ClF₃N₆O₃S₂
SMILES

O=S(C1=CC(F)=CC=C1F)(NC2=CC(Cl)=CC(C3=C(C4=NC(N)=NC=C4)SC(C5NCCOC5)=N3)=C2F)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Schneider M, et al. Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding. J Med Chem. 2022;65(2):1552-1566. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
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순도&문서
References

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B-Raf IN 5

All Raf Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

B-Raf IN 5 Related Classifications

HY-142820 Related Classifications