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Bicuculline methochloride

(Synonyms: (-)-Bicuculline methochloride)
43 Cited Publications
고객리뷰

Based on 43 publication(s) in Google Scholar

Bicuculline ((+)-Bicuculline; d-Bicuculline) methochloride is a selective GABAA receptor antagonist with an IC50 value of 3 μM. Bicuculline methochloride induces clonic tonic convulsions in mammals and can also be used to block Ca2+ activated potassium channels. Bicuculline methochloride can be used in studies of epilepsy and other related psychiatric disorders.

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  • Purity: 99.80%
  • CAS No.: 38641-83-7
  • 화학식: C21H20ClNO6
  • 분자량:417.84
  • 보관:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Bicuculline methochloride Chemical Structure
    Bicuculline methochloride Chemical Structure
  • Experimental Validation Results for Bicuculline methochloride
  • Experimental Validation Results for Bicuculline methochloride
  • Experimental Validation Results for Bicuculline methochloride
  • Experimental Validation Results for Bicuculline methochloride
  • Experimental Validation Results for Bicuculline methochloride
CAS No.: 38641-83-7
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  • Bicuculline methochloride Chemical Structure
    Bicuculline methochloride Chemical Structure
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    Bicuculline methochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 20:e07908. [Abstract]

    Customer Validation
     GABAA receptor antagonist (Bicuculline, 5 µg/10 µL, i.t.) weakened acute morphine analgesic effect.

  • 1/16

    Bicuculline methochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec 16:e2407387. [Abstract]

    Customer Validation
     Bicuculline (100 ng; 0.5 μL; infusion pump). Paw withdrawal responses to the 0.07 g von Frey filament following mPFC injection of physiological saline or Bicuculline (Bic) within 2 hours after intraperitoneal PTX injection.

  • 1/16

    Bicuculline methochloride purchased from MedChemExpress. Usage Cited in: Cell. 2023 Mar 30;186(7):1352-1368.e18. [Abstract]

    Customer Validation
     The antidepressant-like effect of activation of MGA1 in the FST was attenuated by A1 infusion of Bicuculline (BIC, 20 μM; infusion pump).

  • 1/16

    Bicuculline methochloride purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Mar 28;12(7):3057-3078. [Abstract]

    Customer Validation
     Bicuculline (3.5 mg/kg; subcutaneous injections). Western blot analyses of Gabra1, Gabra3, Gabra5, Gabrb3, Gabrg2, KCC2 and GAPDH in the lesion sites from different groups at 4 wpt.

  • 1/16

    Bicuculline methochloride purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Mar 28;12(7):3057-3078. [Abstract]

    Customer Validation
     Bicuculline (3.5 mg/kg; subcutaneous injections). Representative IF images of transverse spinal cord sections from the Intact, +PBS, +PBS+Bic, +MSC, and +MSC+Bic groups at 4 wpt.

  • Bicuculline methochloride