Dichamanetin
Dichamanetin, a C-benzylated flavanone that can be isolated from Piper sarmentosum, is a potent antibacterial and anticancer agent. Dichamanetin displays antibacterial activity against a panel of Gram-positive strains, including resistant S. aureus strains with MIC values in the range of 1-7.5 μg/mL. Dichamanetin inhibits cancer cell growth by affecting ROS-related signaling components via mitochondrial-mediated apoptosis. Dichamanetin can be used for colon, prostate, breast cancer and infection research.
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- CAS No.: 58779-09-2
- 화학식: C29H24O6
- 분자량:468.50
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | GI |
75 %
Compound: 15
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Cytotoxicity against HEK293 cells assessed as growth inhibition at 40 uM relative to control
Cytotoxicity against HEK293 cells assessed as growth inhibition at 40 uM relative to control
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[PMID: 32067457] |
| HL-60 | ED50 |
>20 μM
Compound: 7
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Inhibition of chymotrypsin-like activity of purified human 20S proteasome in HL60 cells using N-succinyl-Leu-Leu-Val-Tyr-AMC as substrate pre-incubated for 10 mins by fluorimetric assay
Inhibition of chymotrypsin-like activity of purified human 20S proteasome in HL60 cells using N-succinyl-Leu-Leu-Val-Tyr-AMC as substrate pre-incubated for 10 mins by fluorimetric assay
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[PMID: 21973101] |
| HT-29 | ED50 |
>20 μM
Compound: 7
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Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay
Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay
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[PMID: 21973101] |
| HT-29 | ED50 |
3.6 μM
Compound: 7
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Induction of apoptosis in human HT-29 cells assessed reduction of mitochondrial membrane potential after 2 hrs by using JC1 staining by fluorescence cell-based assay
Induction of apoptosis in human HT-29 cells assessed reduction of mitochondrial membrane potential after 2 hrs by using JC1 staining by fluorescence cell-based assay
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[PMID: 21973101] |
Chemical Information
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CAS No. 58779-09-2
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분자량 468.50
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화학식 C29H24O6
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SMILES
OC(C(CC1=C(C=CC=C1)O)=C2O)=C(C(C[C@@H](C3=CC=CC=C3)O4)=O)C4=C2CC5=C(C=CC=C5)O
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Structure Classification
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Yong Y, et al. Dichamanetin inhibits cancer cell growth by affecting ROS-related signaling components through mitochondrial-mediated apoptosis. Anticancer Res. 2013 Dec;33(12):5349-55. [Content Brief]
[2]. Pereira F, et al. Cleistochlamys kirkii chemical constituents: Antibacterial activity and synergistic effects against resistant Staphylococcus aureus strains. J Ethnopharmacol. 2016 Feb 3;178:180-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dichamanetin Related Classifications
HY-N12686 Related Classifications
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