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Cat. No.: HY-186074

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ERβ agonist-2

ERβ agonist-2 (Page 72) is a selective ERβ agonist with an EC₅₀ of 800 nM or lower. ERβ agonist-2 selectively inhibits T cell activation and/or proliferation, thereby reducing circulating T cell levels in subjects, without exerting significant effects on circulating neutrophil, monocyte or B cell levels. ERβ agonist-2 is applicable to studies of chronic heart failure after myocardial infarction, as well as graft-versus-host disease, multiple sclerosis and experimental autoimmune encephalomyelitis.

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CAS No.: 628321-25-5
화학식: C₁₉H₁₆N₂O₂
분자량:304.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

ERβ agonist-2 Chemical Structure

CAS No.: 628321-25-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
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Biological Activity

제품 설명

IC₅₀ & Target^[1]

ERβ

800 or low nM (EC₅₀)

All Estrogen Receptor/ERR Isoforms :

In Vitro

ERβ agonist-2 exhibits an EC₅₀ of 800 nM or less at estrogen receptor β (ERβ)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 628321-25-5
분자량 304.34
화학식 C₁₉H₁₆N₂O₂
SMILES

OC1=CC=C(C2=C(C3=C(C)ON=C3C)NC4=C2C=CC=C4)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Shyam BANSAL, et al. Methods of modulating t-cell activation using estrogen receptor beta (erβ) agonists. WO2021183760A1. WIPO (PCT). 2021-03-11.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ERβ agonist-2

All Estrogen Receptor/ERR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ERβ agonist-2 Related Classifications

HY-186074 Related Classifications