628321-25-5
Chemical Structure
ERβ agonist-2
- CAS No.: 628321-25-5
- Formula:C19H16N2O2
- Molecular Weight:304.34
InChIKey: JOIQPSICRVAXSP-UHFFFAOYSA-N
SMILES: OC1=CC=C(C2=C(C3=C(C)ON=C3C)NC4=C2C=CC=C4)C=C1
Biological Activity: ERβ agonist-2 (Page 72) is a selective ERβ agonist with an EC50 of 800 nM or lower. ERβ agonist-2 selectively inhibits T cell activation and/or proliferation, thereby reducing circulating T cell levels in subjects, without exerting significant effects on circulating neutrophil, monocyte or B cell levels. ERβ agonist-2 is applicable to studies of chronic heart failure after myocardial infarction, as well as graft-versus-host disease, multiple sclerosis and experimental autoimmune encephalomyelitis[1].
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ERβ agonist-2 | ERβ agonist-2 (Page 72) is a selective ERβ agonist with an EC50 of 800 nM or lower. ERβ agonist-2 selectively inhibits T cell activation and/or proliferation, thereby reducing circulating T cell levels in subjects, without exerting significant effects on circulating neutrophil, monocyte or B cell levels. ERβ agonist-2 is applicable to studies of chronic heart failure after myocardial infarction, as well as graft-versus-host disease, multiple sclerosis and experimental autoimmune encephalomyelitis. | |||||||||||||||||||||
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Keywords
