Umps - uridine monophosphate synthetase Gene

Also Known as 1700095D23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22247

Summary

Enables orotate phosphoribosyltransferase activity and orotidine-5'-phosphate decarboxylase activity. Involved in 'de novo' UMP biosynthetic process and UDP biosynthetic process. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; limb bud; metanephros; pancreas; and surface ectoderm. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase). [provided by Alliance of Genome Resources, Apr 2022]

Umps Products (2)

mRNA Protein Name
NM_001348087.1 NP_001335016.1 uridine 5'-monophosphate synthase isoform 2
NM_009471.3 NP_033497.1 uridine 5'-monophosphate synthase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables orotate phosphoribosyltransferase activity IDA
IDA: Inferred from direct assay
965379 MGI
enables orotidine-5'-phosphate decarboxylase activity IDA
IDA: Inferred from direct assay
965379 MGI
Biological Process GO Annotation Evidence References Source
involved in 'de novo' UMP biosynthetic process IDA
IDA: Inferred from direct assay
2419341 MGI
involved in 'de novo' UMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
6154574 MGI
involved in UDP biosynthetic process IDA
IDA: Inferred from direct assay
2419341 MGI
involved in UDP biosynthetic process IMP
IMP: Inferred from mutant phenotype
6154574 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

uridine 5'-monophosphate synthase

  • UMP synthase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-N0157 Orotic acid Chemical 99.98% Unkown
HY-N0157R Orotic acid (Standard) Chemical 99.51% Unkown
HY-N0157A Orotic acid zinc Chemical 99.84% Unkown

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-131892 2-Deoxy-D-galactose 99.90% Unkown
HY-N0157S1 Orotic acid-13C,15N2 monohydrate 99.93% Unkown
HY-W009216R 2'-Deoxycytidine-5'-monophosphate (Standard) 99.60% Unkown
HY-129963 3'-UMP disodium 98.92% Unkown
HY-E70122 Uridylate kinase / Unkown
HY-N7396 UMP-morpholidate 98.01% Unkown
HY-137607A UMP-CP trisodium Agonist / Unkown
HY-E71041 Cytidine deaminase, Human / Unkown
HY-RS15461 UMPS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131822 5'-UMPS Agonist / Unkown
HY-137604A (γ-AmNS)UTP trisodium / Unkown
HY-160674 2',3'-Cyclic UMP / Unkown
HY-171515 2'-F-UMP / Unkown
HY-171516 2′-OMe-UMP / Unkown
HY-N8060 Orotidine 5′-monophosphate / Unkown
HY-RS19648 Umps Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26141 Umps Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W826156A 6-Aza-UMP disodium Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Umps NCBI NCBI:7372