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Cat. No.: HY-152032

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LSD1-IN-23

LSD1-IN-23 is a competitive/non-competitive mixed inhibitor of lysine specific demethylase 1 (LSD1). LSD1-IN-23 has LSD1 inhibitory activity with an IC₅₀ value of 0.58 μM. LSD1-IN-23 can be used for the research of neuroblastoma (NB).

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CAS No.: 3033660-66-8
화학식: C₁₉H₁₃BrClN₅O₂S
분자량:490.76

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

LSD1-IN-23 Chemical Structure

CAS No.: 3033660-66-8

사이즈

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재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

KDM1/LSD1

0.58 μM (IC₅₀)

All Histone Demethylase Isoforms :

In Vitro

LSD1-IN-23 (Compound 48) (0-100 μM) exhibits effective LSD1 inhibitory activity with an IC₅₀ value of 0.58 μM^[1].
LSD1-IN-23 (0.005, 0.037, 0.111, 0.333 μM; 72 h) significantly increases global H3K4Me2 in NB cells^[1].
LSD1-IN-23 (0.1 μM; 24 h) has synergistic effect combination treatment with Bortezomib in NB cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

CHP134 and IMR32 cells
Concentration:

0.1 μM
Incubation Time:

24 h
Result:

Enhanced cytotoxicity in MYCN-amplified NB cells combination treatment of bortezomib with compound 48.

Chemical Information

CAS No. 3033660-66-8
분자량 490.76
화학식 C₁₉H₁₃BrClN₅O₂S
SMILES

O=S(NC(C=CC(Br)=C1)=C1C2=NNN=N2)(C3=CC=C(C=C3)C4=CC=C(C=C4)Cl)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Catherine M Mills, et al. Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma. Eur J Med Chem. 2022 Dec 15;244:114818. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
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LSD1-IN-23

All Histone Demethylase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

LSD1-IN-23 Related Classifications

HY-152032 Related Classifications