Nafimidone hydrochloride
Nafimidone is a stable and brain-penetrant antiepileptic compound. Nafimidone shows effective anticonvulsant effects in kindled amygdaloid seizure model. Nafimidone exhibits the narrow effective window, and has obvious epileptogenic effects at high doses. Nafimidone can be used for the study of epilepsy.
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- CAS No.: 70891-37-1
- 화학식: C15H13ClN2O
- 분자량:272.73
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kindled amygdaloid seizures established in Sprague-Dawley rats[1]
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Dosage:0, 3.1, 6.25, 12.5, 25, 50, 100, 120 mg/kg
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Administration:Intraperitoneal injection (i.p.), single dose
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Result:Significantly reduced in seizure rank and AD duration was noted at 25mg/kg after 30 min. Resulted in a reduction of elicited seizure rank and a significant reduction in AD duration at 50 mg/kg. Had drug-induced spontaneous seizures and led to the death of the rats at 100 mg/kg and 120 mg/kg. Significantly reduced elicited seizure rank scores at 15 and 30 min and return to the control level at 180 minutes at a dose of 25mg/kg.
Chemical Information
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CAS No. 70891-37-1
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분자량 272.73
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화학식 C15H13ClN2O
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SMILES
O=C(CN1C=NC=C1)C2=CC3=C(C=CC=C3)C=C2.Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nafimidone hydrochloride Related Classifications
HY-165514A Related Classifications
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