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Cat. No.: HY-161886

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SMARCA2-IN-7

SMARCA2-IN-7 (compound 12), a dual inhibitor of BRM and BRG1 (IC₅₀ < 0.005 for both), has an anti-tumor proliferation effect that inhibits BRG1-deleted SKMEL5 tumor proliferation with a cell proliferation activity AAC₅₀ of 13 nM in SKMEL5. The cell proliferation activity AAC₅₀ of KRT880 in H1299 cells was 42 nM.

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CAS No.: 2270879-43-9
화학식: C₁₁H₉ClF₂N₄O₂S
분자량:334.73

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

SMARCA2-IN-7 Chemical Structure

CAS No.: 2270879-43-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- Cellular Effect
Chemical Information
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Bioz

Biological Activity

제품 설명

All SWI/SNF Complex Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SBC-5	EC₅₀	>10 μM Compound: 12	Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay	[PMID: 30339381]

Chemical Information

CAS No. 2270879-43-9
분자량 334.73
화학식 C₁₁H₉ClF₂N₄O₂S
SMILES

O=C(NC1=CC(C(F)F)=NS1)NC2=CC(Cl)=NC=C2CO
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Papillon JPN,et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. Medicinal Chemistry. 2018 Nov 21;61(22):10155-10172. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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SMARCA2-IN-7

All SWI/SNF Complex Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SMARCA2-IN-7 Related Classifications

HY-161886 Related Classifications