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Cat. No.: HY-184272

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SphK2-IN-5

SphK2-IN-5 is a selective SphK2 inhibitor with an IC₅₀ of 0.55 μM. SphK2-IN-5 exhibits anticancer activity against colon cancer and liver cancer.

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화학식: C₂₀H₁₅N₃O₅S
분자량:409.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SphK2-IN-5 Chemical Structure

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재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

SphK2-IN-5 is a selective SphK2 inhibitor with an IC₅₀ of 0.55 μM. SphK2-IN-5 exhibits anticancer activity against colon cancer and liver cancer^[1].

IC₅₀ & Target^[1]

SphK2

0.55 μM (IC₅₀)

All SphK Isoforms :

SphK1
SphK2

In Vitro

SphK2-IN-5 (Compound 6a) potently and selectively inhibits SphK2 with an IC₅₀ of 0.55 μM; it shows negligible activity against SphK1 at a concentration of 10 μM^[1].
SphK2-IN-5 (48 h) exhibits potent and selective antiproliferative activity against the HCT-116, MC38, Hepa1-6 and HepG2 tumor cell lines, and shows no activity against non-tumorigenic NIH-3T3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MCF-7, HCT-116, MC38, Hepa1-6, HepG2, NIH-3T3
Concentration:

Different concentrations
Incubation Time:

48 h
Result:

Showed IC₅₀s of >100 μM, 10.43 μM, 1.45 μM, 9.57 μM, 0.23 μM, >100 μM for MCF-7, HCT-116, MC38, Hepa1-6, HepG2, NIH-3T3, respectively.

Chemical Information

분자량 409.42
화학식 C₂₀H₁₅N₃O₅S
SMILES

O=C(NC/1=O)SC1=C\C2=CN(CCOC3=CC=C([N+]([O-])=O)C=C3)C4=C2C=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhang M, et al. Discovery of 1,3-disubstituted indole derivatives as ATP-competitive inhibitors of sphingosine kinase for tumor therapy. European journal of medicinal chemistry. 2026 May 22;316:118983. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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SphK2-IN-5

All SphK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SphK2-IN-5 Related Classifications

HY-184272 Related Classifications