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Cat. No.: HY-N16376

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Thienodolin

(Synonyms: MJ 286A)

Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus. Thienodolin inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 murine macrophage cells with an IC₅₀ value of 17.2 μM. Thienodolin suppresses iNOS, blocks the degradation of IκBα, attenuates NF-κB p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation.

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CAS No.: 149127-27-5
화학식: C₁₁H₇ClN₂OS
분자량:250.70

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Thienodolin Chemical Structure

CAS No.: 149127-27-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All NF-κB Isoforms :

All STAT Isoforms :

In Vitro

Thienodolin (6.25-50 μM, 15 min pretreatment) inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 cells (IC₅₀ = 17.2 μM)^[1].
Thienodolin (6.25-50 μM, 5-18 h) suppresses iNOS expression in a dose-dependent manner at both mRNA and protein levels in LPS-stimulated RAW 264.7 cells^[1].
Thienodolin (6.25-50 μM, 15 min pretreatment) blocks the degradation of IκBα, reduces the phosphorylation level of STAT1 at Tyr701 and attenuates NF-κB p65 accumulation in the nucleus in LPS-stimulated RAW 264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

LPS-stimulated RAW 264.7 cells
Concentration:

6.25, 12.5, 25, 50 μM
Incubation Time:

15 min pretreatment
Result:

Blocked the degradation of IκBα.
Reduced the phosphorylation level of STAT1 at Tyr701.
Attenuated NF-κB p65 accumulation in the nucleus.

Chemical Information

CAS No. 149127-27-5
분자량 250.70
화학식 C₁₁H₇ClN₂OS
SMILES

O=C(C1=CC2=C(NC3=C2C=CC(Cl)=C3)S1)N
Synonyms

MJ 286A
Structure Classification
- Alkaloids
- Pyridine Alkaloids
Initial Source
- Microorganisms
Streptomyces albogriseolus
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Park EJ, et al. Suppression of nitric oxide synthase by thienodolin in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. Nat Prod Commun. 2012 Jun;7(6):789-94. [Content Brief]

Calculators

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Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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CAS No.:
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Purity:
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Thienodolin

All NF-κB Isoforms

All STAT Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Thienodolin Related Classifications

HY-N16376 Related Classifications