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Cat. No.: HY-184285

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TLR2 antagonist-2

TLR2 antagonist-2 is a selective TLR2 antagonist with an IC₅₀ of 0.94 μM. TLR2 antagonist-2 inhibits TLR1/2 and TLR2/6 heterodimers. TLR2 antagonist-2 is applicable to the research of inflammatory diseases.

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화학식: C₂₃H₁₃F₃N₂O₃
분자량:422.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

TLR2 antagonist-2 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

TLR2

0.94 μM (IC₅₀)

All Toll-like Receptor (TLR) Isoforms :

In Vitro

TLR2 antagonist-2 (Compound b1) potently inhibits the Pam3CSK4-induced TLR2 signaling pathway in HEK-Blue hTLR2 cells, with an IC₅₀ value of 0.94 μM^[1].
TLR2 antagonist-2 (increasing concentrations; 24 h) selectively inhibits the signaling pathways of TLR1/2 and TLR2/6 heterodimers in THP1-Dual reporter cells, and shows no activity against TLR4 or TLR7/8 signaling pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 422.36
화학식 C₂₃H₁₃F₃N₂O₃
SMILES

O=C(C1=CC(C2=CC(C=O)=C(O)C(F)=C2)=NC3=CC=CC=C13)NC4=CC=C(F)C=C4F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Jin H, et al. Design, synthesis, and evaluation of 3-fluoro-2-hydroxybenzaldehyde derivatives as TLR2 small molecule antagonists. Bioorganic chemistry. 2026 Jun 08;180:110062. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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TLR2 antagonist-2

All Toll-like Receptor (TLR) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

TLR2 antagonist-2 Related Classifications

HY-184285 Related Classifications