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Cat. No.: HY-144451

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TRK-IN-12

TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRK^G595R IC₅₀ = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC₅₀ = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC₅₀ = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line.

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CAS No.: 2823342-34-1
화학식: C₁₈H₁₉ClFN₅O₃S
분자량:439.89

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

TRK-IN-12 Chemical Structure

CAS No.: 2823342-34-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Trk Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	0.08 μM Compound: 9e	Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1 Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1	[PMID: 34628036]
BaF3	IC₅₀	0.646 μM Compound: 9e	Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1 G595R mutant Antiproliferative activity against mouse BaF3 cells harboring LMNA fused NTRKA1 G595R mutant	[PMID: 34628036]

Chemical Information

CAS No. 2823342-34-1
분자량 439.89
화학식 C₁₈H₁₉ClFN₅O₃S
SMILES

CN1CC2=CC(F)=CC=C2OCCN(CC3=C4N=C1C=CN4N=C3)S(=O)(CCl)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li P, et al. Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors [published correction appears in Bioorg Med Chem Lett. 2022 Jan 15;56:128502]. Bioorg Med Chem Lett. 2021;53:128409. [Content Brief]

Calculators

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Mass Mass

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Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
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TRK-IN-12

All Trk Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

TRK-IN-12 Related Classifications

HY-144451 Related Classifications