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Cat. No.: HY-176704

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USP1-IN-13

USP1-IN-13 (Compound 2) is a potent and orally active USP1 inhibitor with an IC₅₀ value of 1.02 nM. USP1-IN-13 can be used for the study of breast cancer.

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CAS No.: 2974433-50-4
화학식: C₃₀H₃₃F₄N₇O
분자량:583.62

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

USP1-IN-13 Chemical Structure

CAS No.: 2974433-50-4

사이즈

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재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

USP1-IN-13 (Compound 2) is a potent and orally active USP1 inhibitor with an IC₅₀ value of 1.02 nM. USP1-IN-13 can be used for the study of breast cancer^[1].

IC₅₀ & Target^[1]

USP1

1.02 nM (IC₅₀)

All Deubiquitinase Isoforms :

In Vitro

USP1-IN-13 (Compound 2) (14 d) inhibits the colony-forming ability of MDA-MB-436 cells, with its IC₅₀ value being 31.34 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	AUC_0-t
Mice^[1]	10 mg/kg	i.g.	1432 ng/mL	9888 ng·h/mL

Chemical Information

CAS No. 2974433-50-4
분자량 583.62
화학식 C₃₀H₃₃F₄N₇O
SMILES

COC1=C(C(C2CC2)=NC=N1)C3=C(C4=C(C=NN4CC56CCC(CC5)(CC6)C7=NC(C(F)(F)F)=CN7C(C)C)C=N3)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. ChenZhang, et al. Azacyclic derivative and medical application thereof. WO2023143424A1.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

USP1-IN-13

All Deubiquitinase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

USP1-IN-13 Related Classifications

HY-176704 Related Classifications