XMU-MP-9
Based on 1 Customer Validation
XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used for the study of colon, lung and pancreatic cancer.
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- Purity: 99.12%
- CAS No.: 2251130-41-1
- 화학식: C19H13ClFN3OS
- 분자량:385.84
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보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
XMU-MP-9 (10 μM; 48 h) promotes the degradation of K-RasG12V via the lysosomal pathway in SW620 cells[1].
XMU-MP-9 (2-20 μM) inhibits the proliferation of cancer cells (SW620, AsPC-1, etc.) carrying K-Ras mutants in 2-D culture[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice with CT-26 transplant tumors[1]
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Dosage:40 mg/kg, 80 mg/kg
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Administration:Tail vein injection; once or twice daily
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Result:Showed more robust inhibitory effect on CT-26 transplant tumors in BALB/c mice.
Decreased K-RasG12V levels and phosphorylation of B-Raf and MEK in tumors.
Showed no significant weight loss or toxicity to heart, liver, spleen, lung, or kidney.
Chemical Information
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CAS No. 2251130-41-1
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Appearance Solid
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분자량 385.84
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화학식 C19H13ClFN3OS
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Color White to off-white
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SMILES
FC1=C(CNC(C2=CSC(C3=NNC4=CC=CC=C34)=C2)=O)C(Cl)=CC=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
DMSO : 116.67 mg/mL (302.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5917 mL | 12.9587 mL | 25.9175 mL | 64.7937 mL |
| 5 mM | 0.5183 mL | 2.5917 mL | 5.1835 mL | 12.9587 mL | |
| 10 mM | 0.2592 mL | 1.2959 mL | 2.5917 mL | 6.4794 mL | |
| 15 mM | 0.1728 mL | 0.8639 mL | 1.7278 mL | 4.3196 mL | |
| 20 mM | 0.1296 mL | 0.6479 mL | 1.2959 mL | 3.2397 mL | |
| 25 mM | 0.1037 mL | 0.5183 mL | 1.0367 mL | 2.5917 mL | |
| 30 mM | 0.0864 mL | 0.4320 mL | 0.8639 mL | 2.1598 mL | |
| 40 mM | 0.0648 mL | 0.3240 mL | 0.6479 mL | 1.6198 mL | |
| 50 mM | 0.0518 mL | 0.2592 mL | 0.5183 mL | 1.2959 mL | |
| 60 mM | 0.0432 mL | 0.2160 mL | 0.4320 mL | 1.0799 mL | |
| 80 mM | 0.0324 mL | 0.1620 mL | 0.3240 mL | 0.8099 mL | |
| 100 mM | 0.0259 mL | 0.1296 mL | 0.2592 mL | 0.6479 mL |
XMU-MP-9 Related Classifications
HY-162809 Related Classifications
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