2. Anti-infection Cell Cycle/DNA Damage
  3. CMV p97
  4. LC-1310

LC-1310 is an antiviral agent that targets and inhibits p97, and it suppresses the in vitro replication of human cytomegalovirus (HCMV) with an EC50 value of 0.3 μM. LC-1310 targets the D2 ATP-binding site of p97, downregulates the expression of early viral proteins, thereby blocking the transcription and proliferation of early viral genes. LC-1310 can be used for research on human cytomegalovirus infection.

For research use only. We do not sell to patients.

LC-1310

LC-1310 Chemical Structure

CAS No. : 2322268-24-4

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LC-1310 Related Antibodies

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Description

LC-1310 is an antiviral agent that targets and inhibits p97, and it suppresses the in vitro replication of human cytomegalovirus (HCMV) with an EC50 value of 0.3 μM. LC-1310 targets the D2 ATP-binding site of p97, downregulates the expression of early viral proteins, thereby blocking the transcription and proliferation of early viral genes. LC-1310 can be used for research on human cytomegalovirus infection[1].

In Vitro

LC-1310 (6 days) potently inhibits human cytomegalovirus replication in primary human foreskin fibroblasts with an EC50 of 0.3 μM, exhibits low cellular toxicity with a CC50 of 12 μM, and has a therapeutic index of 40[1].
LC-1310 reduces the expression of both HCMV IE1 and HCMV IE2 proteins in primary human foreskin fibroblasts starting 2 days post-viral inoculation and continuing through day 5[1].
LC-1310 (0.01-1 μM; 6 days) combined with Ganciclovir (HY-13637) produces a synergistic inhibitory effect on human cytomegalovirus replication in primary human foreskin fibroblasts, with no significant associated cellular toxicity[1].
LC-1310 (0.01-1 μM; 6 days) combined with Letermovir (HY-15233) produces an additive inhibitory effect on human cytomegalovirus replication in primary human foreskin fibroblasts, with no significant associated cellular toxicity[1].
LC-1310 (0.1-0.5 μM; 1-5 days) did not show detectable antiviral activity against influenza A virus (A/WS/33) and human coronavirus OC43 in Huh7 human hepatocellular carcinoma cells in Madin-Darby canine kidney cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LC-1310 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: primary human foreskin fibroblasts
Concentration: 0.01, 0.03, 0.1, 0.3, 1 μM
Incubation Time: 6 days
Result: Combined with Ganciclovir (HY-13637) produces a synergistic inhibitory effect on human cytomegalovirus replication in primary human foreskin fibroblasts, with no significant associated cellular toxicity.
Combined with Letermovir (HY-15233) produces an additive inhibitory effect on human cytomegalovirus replication in primary human foreskin fibroblasts, with no significant associated cellular toxicity.
Molecular Weight

439.51

Formula

C26H25N5O2
CAS No.
SMILES

O=C(NC1=CC=CC2=C1C=C(C)N2C3=NC(CCOC4)=C4C(NCC5=CC=CC=C5)=N3)C=C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LC-1310 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LC-13102322268-24-4LC1310LC 1310CMVp97CytomegalovirusVCPCdc48human cytomegalovirusHCMV IE1influenza A virus (A/WS/33)HCMV IE2primary human foreskin fibroblastsMadin-Darby Canine Kidney cellshuman coronavirus OC43Huh7 human hepatocellular carcinoma cellsD2 ATP binding siteInhibitorinhibitorinhibit

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