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  2. LCKLSL hydrochloride

LCKLSL hydrochloride 

Cat. No.: HY-P2333A
Handling Instructions

LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL hydrochloride also inhibits the generation of plasmin and has anti-angiogenic roles.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

LCKLSL hydrochloride Chemical Structure

LCKLSL hydrochloride Chemical Structure

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5 mg USD 250 Ask For Quote & Lead Time
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Description

LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL hydrochloride also inhibits the generation of plasmin and has anti-angiogenic roles[1].

IC50 & Target

Annexin A2 (AnxA2)[1]

In Vitro

In human retinal microvascular endothelial cells (RMVECs), treatment with LCKLSL (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions[1].

In Vivo

Application of LCKLSL in two in vivo models (in chicken chorioallantoic membrane and murine Matrigel plug assays) of angiogenesis demonstrates suppression of the angiogenic responses. Treatment with the LCKLSL peptide significantly decreases the vascular length. At a dose of 5 μg/mL, the LCKLSL peptide significantly decreases the number of vascular branches, junctions and end-points[1].

Molecular Weight

712.34

Formula

C₃₀H₅₈ClN₇O₈S

Sequence

Leu-Cys-Lys-Leu-Ser-Leu

Sequence Shortening

LCKLSL

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

LCKLSLOthersAnti-proteolyticneovascularizationplasminAnxA2anti-angiogenictPAN-terminalhexapeptideInhibitorinhibitorinhibit

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Product name:
LCKLSL hydrochloride
Cat. No.:
HY-P2333A
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