LCKLSL
Based on 8 publication(s) in Google Scholar
LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles.
For research use only. We do not sell to patients.
- Purity: 99.26%
- CAS No.: 533902-29-3
- Formula: C30H57N7O8S
- Molecular Weight:675.88
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) LCKLSL
More- J Extracell Vesicles. 2024 Apr;13(4):e12425. [Abstract]
- J Immunother Cancer. 2025 Jun 26;13(6):e011716. [Abstract]
- Cell Commun Signal. 2024 Dec 21;22(1):616. [Abstract]
- Biomed Pharmacother. 2023 Mar:159:114173. [Abstract]
- Biochem Pharmacol. 2025 Sep 6;242(Pt 2):117308. [Abstract]
- Inflamm Res. 2022 Sep;71(9):1067-1078. [Abstract]
- iScience. 2025 Apr 2;28(5):112302. [Abstract]
- J Neurochem. 2022 Mar;160(6):662-674. [Abstract]
Customer Validation & Images
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WB
Biological Activity
Annexin A2 (AnxA2)[1]
In human retinal microvascular endothelial cells (RMVECs), treatment with LCKLSL (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 533902-29-3
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Appearance Solid
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Molecular Weight 675.88
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Formula C30H57N7O8S
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Color White to off-white
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Sequence
Leu-Cys-Lys-Leu-Ser-Leu
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Sequence Shortening
LCKLSL
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (8)
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Journal Impact Factor
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Most Recent
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J Extracell Vesicles
2024 Apr;13(4):e12425. PMID: 38594791 -
J Immunother Cancer
Targeting Annexin A2 to reactivate tumor-associated antigens presentation and relieve immune tolerance in liver cancer. [Abstract]2025 Jun 26;13(6):e011716. PMID: 40571481 -
Cell Commun Signal
Exosomal ANXA2 facilitates ovarian cancer peritoneal metastasis by activating peritoneal mesothelial cells through binding with TLR2. [Abstract]2024 Dec 21;22(1):616. PMID: 39709496 -
Biomed Pharmacother
Isoliquiritigenin alleviates the development of alcoholic liver fibrosis by inhibiting ANXA2. [Abstract]2023 Mar:159:114173. PMID: 36680814
LCKLSL purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Mar:159:114173. [Abstract]
LCKLSL (5 μM) intervention significantly inhibits ANXA2 protein expression levels when compare to the alcohol group, in activated HSC-T6 cells.
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Biochem Pharmacol
Isoliquiritigenin inhibits the activation of the ANXA2/STAT3 pathway by down-regulating TAGLN2, thereby alleviating alcoholic fatty liver. [Abstract]2025 Sep 6;242(Pt 2):117308. PMID: 40921221 -
Inflamm Res
Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF-κB signaling pathway. [Abstract]2022 Sep;71(9):1067-1078. PMID: 35900381 -
iScience
Humanized mouse model reveals T cell ANXA2 as a potential therapeutic target in ischemic stroke. [Abstract]2025 Apr 2;28(5):112302. PMID: 40641552 -
J Neurochem
Activation of Annexin A2 signaling at the blood-brain barrier in a mouse model of multiple sclerosis. [Abstract]2022 Mar;160(6):662-674. PMID: 35064931
Solvent & Solubility
H2O : ≥ 50 mg/mL (73.98 mM)
DMSO : 5 mg/mL (7.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.4796 mL | 7.3978 mL | 14.7955 mL | 36.9888 mL |
| 5 mM | 0.2959 mL | 1.4796 mL | 2.9591 mL | 7.3978 mL | |
| H2O | 10 mM | 0.1480 mL | 0.7398 mL | 1.4796 mL | 3.6989 mL |
| 15 mM | 0.0986 mL | 0.4932 mL | 0.9864 mL | 2.4659 mL | |
| 20 mM | 0.0740 mL | 0.3699 mL | 0.7398 mL | 1.8494 mL | |
| 25 mM | 0.0592 mL | 0.2959 mL | 0.5918 mL | 1.4796 mL | |
| 30 mM | 0.0493 mL | 0.2466 mL | 0.4932 mL | 1.2330 mL | |
| 40 mM | 0.0370 mL | 0.1849 mL | 0.3699 mL | 0.9247 mL | |
| 50 mM | 0.0296 mL | 0.1480 mL | 0.2959 mL | 0.7398 mL | |
| 60 mM | 0.0247 mL | 0.1233 mL | 0.2466 mL | 0.6165 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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