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LCKLSL 

Cat. No.: HY-P2333
Handling Instructions

LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

LCKLSL Chemical Structure

LCKLSL Chemical Structure

CAS No. : 533902-29-3

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Description

LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles[1].

IC50 & Target

Annexin A2 (AnxA2)[1]

In Vitro

In human retinal microvascular endothelial cells (RMVECs), treatment with LCKLSL (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Application of LCKLSL in two in vivo models (in chicken chorioallantoic membrane and murine Matrigel plug assays) of angiogenesis demonstrates suppression of the angiogenic responses. Treatment with the LCKLSL peptide significantly decreases the vascular length. At a dose of 5 μg/mL, the LCKLSL peptide significantly decreases the number of vascular branches, junctions and end-points[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

675.88

Formula

C₃₀H₅₇N₇O₈S

CAS No.

533902-29-3

Sequence

Leu-Cys-Lys-Leu-Ser-Leu

Sequence Shortening

LCKLSL

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LCKLSLOthersAnti-proteolyticneovascularizationplasminAnxA2anti-angiogenictPAN-terminalhexapeptideInhibitorinhibitorinhibit

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