1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. LY2444296

LY2444296 (Synonyms: FP3FBZ)

Cat. No.: HY-135230
Handling Instructions

LY2444296 is an orally bioavailable, high-affinity and selective short-acting kappa opioid receptor (KOPR) antagonist, with a Ki value of ∼1 nM. LY2444296 exhibits anti-anxiety like effects.

For research use only. We do not sell to patients.

LY2444296 Chemical Structure

LY2444296 Chemical Structure

CAS No. : 1346133-11-6

Size Price Stock
5 mg USD 80 Ask For Quote & Lead Time
10 mg USD 150 Ask For Quote & Lead Time
50 mg USD 600 Ask For Quote & Lead Time
100 mg USD 1100 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LY2444296 is an orally bioavailable, high-affinity and selective short-acting kappa opioid receptor (KOPR) antagonist, with a Ki value of ∼1 nM. LY2444296 exhibits anti-anxiety like effects[1][2].

IC50 & Target

Ki: ~1 nM (KOPR)[1]

In Vivo

LY2444296 displays anti-anxiety like effects in the EPM test[1].
LY2444296 (3 mg/kg; i.p.; 30 min before U69,593 administration) prevents behavioral and neuroendocrine effects caused by the reference kappa agonist U69,593 in cocaine-naïve rats[2].
LY2444296 reduces anxiety-like and depressive-like behaviors, as well as CORT release, in rats tested after chronic extended access cocaine self-administration, but not in cocaine-naïve rats[2].

Animal Model: Adult male Sprague Dawley rats (240–250 g)[2]
Dosage: 3 mg/kg
Administration: Injected intraperitoneally; 30 min before U69,593 administration
Result: Prevented behavioral and neuroendocrine effects caused by U69,593 in cocaine-naïve rats.
Molecular Weight

408.44

Formula

C₂₄H₂₂F₂N₂O₂

CAS No.

1346133-11-6

SMILES

O=C(N)C1=CC=C(OC2=CC=C(CN3[[email protected]](C4=CC=CC(F)=C4)CCC3)C=C2)C(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

LY2444296FP3FBZLY 2444296LY-2444296Opioid ReceptorKOPRInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
LY2444296
Cat. No.:
HY-135230
Quantity:
MCE Japan Authorized Agent: