MitoTam iodide, hydriodide
Based on 1 Customer Validation
MitoTam iodide, hydriodide is a Tamoxifen derivative, an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology. MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells. MitoTam iodide, hydriodide causes apoptosis.
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- 純度: 95.66%
- CAS 番号: 1634624-74-0
- 分子式: C52H60I2NOP
- 分子量:999.82
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保管条件:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MitoTam (0.5 μM-56 μM; 24 hours) kills breast cancer cell Lines and nonmalignant cells with an IC50 range from 0.65 μM to 55.9 μM[1]. MitoTam (2.5 μM; 2-24 hours) results in stronger activation of the apoptotic pathway in MCF7 Her2high cells compared with mock MCF7 cells[1]. MitoTam (0.05 μM-1 μM; 3 days) causes a concentration-dependent induction of apoptosis in breast cancer cells, while there was no effect for non-malignant breast epithelial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Breast Cancer Cell Lines: BT474, MCF7, MCF7 Her2high, MCF7 Her2low, MDA-MB-231, MDA-MB-436, MDA-MB-453, SK-BR-3, T47D; NeuTL cells; Nonmalignant Cells: A014578, H9c2 cells
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Concentration:0.5 μM-56 μM
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Incubation Time:24 hours
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Result:Killed breast cancer cells MCF7, MCF7 Her2high, MCF7 Her2low with IC50 values of 1.25 μM, 0.65 μM and 1.45 μM respectively.
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Cell Line:MCF7 mock and MCF7 Her2high cells
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Concentration:2.5 μM
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Incubation Time:2 hours, 4 hours, 8 hours, 16 hours, 24 hours
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Result:Revealed accelerated cleavage of procaspase-9, Parp1/2 and proapoptotic Bax and decreased the antiapoptotic Bcl-2 protein in Her2high cells.
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Cell Line:MCF-7, 4T1 and MCF-10a cells
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Concentration:0.05 μM-1 μM
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Incubation Time:3 days
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Result:Resulted in apoptosis in MCF7 and 4T1 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:18-month-old or 2-month-old FVB/N mice[1]
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Dosage:2 μg/g
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Administration:Intraperitoneal injection; 2 μg/g; once a week; 4 weeks
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Result:Eliminated senescent cells also in vivo.
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Animal Model:18-month-old or 2-month-old FVB/N mice[2]
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Dosage:0.54 μmol/mouse
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Administration:Intraperitoneal injection; 0.54 μmol/mouse; twice a week; 2 weeks
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Result:Suppressed Her2high breast carcinomas.
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Animal Model:18-month-old or 2-month-old FVB/N mice[1]
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Dosage:0.25 μmol/mouse
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Administration:Intraperitoneal injection; 0.25 μmol/mouse; twice a week; 2 weeks
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Result:Prevented reaching the ethical endpoint in all situations, slowed down the growth of MCF7 mock tumors and suppressed Her2high carcinomas decreased.
化学情報
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CAS 番号 1634624-74-0
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性状 Solid
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分子量 999.82
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分子式 C52H60I2NOP
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Color White to light yellow
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SMILES
CN(CCOC1=CC=C(/C(C2=CC=CC=C2)=C(C3=CC=CC=C3)/CCCCCCCCCC[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)C=C1)C.[H]I.[I-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
溶剤 & 溶解度
DMSO : 100 mg/mL (100.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
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- Deutsch - DE (252 KB)
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- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Rohlenova K, et al. Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2highBreast Cancer. Antioxid Redox Signal. 2017 Jan 10;26(2):84-103. [Content Brief]
[2]. Hubackova S, et al. Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2. Cell Death Differ. 2019 Jan;26(2):276-290. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0002 mL | 5.0009 mL | 10.0018 mL | 25.0045 mL |
| 5 mM | 0.2000 mL | 1.0002 mL | 2.0004 mL | 5.0009 mL | |
| 10 mM | 0.1000 mL | 0.5001 mL | 1.0002 mL | 2.5005 mL | |
| 15 mM | 0.0667 mL | 0.3334 mL | 0.6668 mL | 1.6670 mL | |
| 20 mM | 0.0500 mL | 0.2500 mL | 0.5001 mL | 1.2502 mL | |
| 25 mM | 0.0400 mL | 0.2000 mL | 0.4001 mL | 1.0002 mL | |
| 30 mM | 0.0333 mL | 0.1667 mL | 0.3334 mL | 0.8335 mL | |
| 40 mM | 0.0250 mL | 0.1250 mL | 0.2500 mL | 0.6251 mL | |
| 50 mM | 0.0200 mL | 0.1000 mL | 0.2000 mL | 0.5001 mL | |
| 60 mM | 0.0167 mL | 0.0833 mL | 0.1667 mL | 0.4167 mL | |
| 80 mM | 0.0125 mL | 0.0625 mL | 0.1250 mL | 0.3126 mL | |
| 100 mM | 0.0100 mL | 0.0500 mL | 0.1000 mL | 0.2500 mL |
MitoTam iodide, hydriodide 関連分類
HY-126222A 関連分類
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