2. PI3K/Akt/mTOR
  3. PIKfyve
  4. MOMIPP

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB).

For research use only. We do not sell to patients.

MOMIPP Chemical Structure

MOMIPP Chemical Structure

CAS No. : 1363421-46-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 457 In-stock
Solution
10 mM * 1 mL in DMSO USD 457 In-stock
Solid
1 mg USD 142 In-stock
5 mg USD 200 In-stock
10 mg USD 320 In-stock
25 mg USD 580 In-stock
50 mg USD 800 In-stock
100 mg USD 1200 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MOMIPP:

MOMIPP Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB)[1][2].

In Vitro

MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations[1].
In U373 and Hs683 cell lines, 3 µM for MOMIPP induces cell vacuolization[1].
MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MOMIPP Related Antibodies

Western Blot Analysis[2]

Cell Line: U251 cells
Concentration: 10 μM
Incubation Time: 4 h or 24 h
Result: Activated the JNK stress kinase pathway.
In Vivo

MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic CrTac:NCR-Foxn1 mice (female, 7-8 weeks)[2]
Dosage: 80 mg/kg
Administration: i.p.; once daily; for 15 consecutive days
Result: Suppressed progression of intracerebral glioblastoma xenografts.
Molecular Weight

292.33

Formula

C18H16N2O2
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(/C=C/C1=C(NC2=C1C=C(C=C2)OC)C)C3=CC=NC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (106.90 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4208 mL 17.1040 mL 34.2079 mL
5 mM 0.6842 mL 3.4208 mL 6.8416 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.37%

COA (250 KB) HNMR (260 KB) LCMS (269 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4208 mL 17.1040 mL 34.2079 mL 85.5198 mL
5 mM 0.6842 mL 3.4208 mL 6.8416 mL 17.1040 mL
10 mM 0.3421 mL 1.7104 mL 3.4208 mL 8.5520 mL
15 mM 0.2281 mL 1.1403 mL 2.2805 mL 5.7013 mL
20 mM 0.1710 mL 0.8552 mL 1.7104 mL 4.2760 mL
25 mM 0.1368 mL 0.6842 mL 1.3683 mL 3.4208 mL
30 mM 0.1140 mL 0.5701 mL 1.1403 mL 2.8507 mL
40 mM 0.0855 mL 0.4276 mL 0.8552 mL 2.1380 mL
50 mM 0.0684 mL 0.3421 mL 0.6842 mL 1.7104 mL
60 mM 0.0570 mL 0.2851 mL 0.5701 mL 1.4253 mL
80 mM 0.0428 mL 0.2138 mL 0.4276 mL 1.0690 mL
100 mM 0.0342 mL 0.1710 mL 0.3421 mL 0.8552 mL
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MOMIPP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MOMIPP1363421-46-8PIKfyveFYVE domain-containing phosphatidylinositol 3-phosphate 5-kinasePhosphatidylinositol 3-phosphate 5-kinaseFab1MacropinocytosisBBBJNK1/2c-JunBcl-2Bcl-xLInhibitorinhibitorinhibit

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