1. PI3K/Akt/mTOR
  2. PIKfyve
  3. MOMIPP

MOMIPP 

Cat. No.: HY-119624
Handling Instructions

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB).

For research use only. We do not sell to patients.

MOMIPP Chemical Structure

MOMIPP Chemical Structure

CAS No. : 1363421-46-8

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Description

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB)[1][2].

In Vitro

MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations[1].
In U373 and Hs683 cell lines, 3 µM for MOMIPP induces cell vacuolization[1].
MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: U251 cells
Concentration: 10 μM
Incubation Time: 4 h or 24 h
Result: Activated the JNK stress kinase pathway.
In Vivo

MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic CrTac:NCR-Foxn1 mice (female, 7-8 weeks)[2]
Dosage: 80 mg/kg
Administration: i.p.; once daily; for 15 consecutive days
Result: Suppressed progression of intracerebral glioblastoma xenografts.
Molecular Weight

292.33

Formula

C₁₈H₁₆N₂O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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MOMIPP
Cat. No.:
HY-119624
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