1363421-46-8
1363421-46-8
Chemical Structure
MOMIPP
- CAS. Nr.: 1363421-46-8
- Formula:C18H16N2O2
- Molecular Weight:292.33
IUPAC Name: (E)-3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one
InChIKey: UPJCYXIOWHZRLU-GQCTYLIASA-N
SMILES: O=C(/C=C/C1=C(NC2=C1C=C(C=C2)OC)C)C3=CC=NC=C3
Biological Activity: MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB)[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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MOMIPP | 99.00% | MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.93
HY-1154586-MOMIPP -
Similarity Score 0.86
HY-148114MOPIPP -
Similarity Score 0.66
HY-101285RDMU2139 (Standard) -
Similarity Score 0.66
HY-126308(E/Z)-DMU2139 -
Similarity Score 0.64
HY-12204PFK-015 -
Similarity Score 0.63
HY-W008567N-Deschlorobenzoyl indomethacin -
Similarity Score 0.63
HY-120377CYP1A1 inhibitor 8a -
Similarity Score 0.62
HY-186151UCI-LC0019 -
Similarity Score 0.62
HY-12203PFK-158 -
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References
- [1]. Margaux Colin, et al. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3):411. [Content Brief]
- [2]. Zehui Li, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77. [Content Brief]
