MS-073
MS-073 (CP162398) is a P-glycoprotein (P-gp) inhibitor. MS-073 reverses multidrug resistance in drug-resistant cells by competitively inhibiting drug binding to P-glycoprotein.
For research use only. We do not sell to patients.
- CAS No.: 129716-45-6
- Formula: C31H33N3O2
- Molecular Weight:479.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHRC5 cell line | EC50 |
65 nM
Compound: MS-073
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Tested for in vitro proliferation and viability of multidrug resistant CHRC5 Chinese hamster cells in the presence and absence of doxorubicin in a modified MTT assay
Tested for in vitro proliferation and viability of multidrug resistant CHRC5 Chinese hamster cells in the presence and absence of doxorubicin in a modified MTT assay
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10.1016/0960-894X(95)00426-T |
Chemical Information
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CAS No. 129716-45-6
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Molecular Weight 479.61
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Formula C31H33N3O2
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SMILES
OC(COC1=C2C=CC=NC2=CC=C1)CN3CCN(CC3)C4C5=CC=CC=C5CCC6=CC=CC=C46
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Synonyms
CP162398
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sato W, et al. Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073[J]. Cancer research, 1991, 51(9): 2420-2424. [Content Brief]
[2]. Smith B J, et al. P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298(3): 1252-1259. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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