129716-45-6
129716-45-6
Chemical Structure
MS-073
Synonym(s): CP162398
- CAS No.: 129716-45-6
- Formula:C31H33N3O2
- Molecular Weight:479.61
IUPAC Name: 1-(4-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)piperazin-1-yl)-3-(quinolin-5-yloxy)propan-2-ol
InChIKey: YLQSXCMKFKBZLE-UHFFFAOYSA-N
SMILES: OC(COC1=C2C=CC=NC2=CC=C1)CN3CCN(CC3)C4C5=CC=CC=C5CCC6=CC=CC=C46
Biological Activity: MS-073 (CP162398) is a P-glycoprotein (P-gp) inhibitor. MS-073 reverses multidrug resistance in drug-resistant cells by competitively inhibiting drug binding to P-glycoprotein[1][2].
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MS-073 | MS-073 (CP162398) is a P-glycoprotein (P-gp) inhibitor. MS-073 reverses multidrug resistance in drug-resistant cells by competitively inhibiting drug binding to P-glycoprotein. | |||||||||||||||||||||
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References
- [1]. Sato W, et al. Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073[J]. Cancer research, 1991, 51(9): 2420-2424. [Content Brief]
- [2]. Smith B J, et al. P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298(3): 1252-1259. [Content Brief]
Keywords
