1. Anti-infection
  2. SARS-CoV
  3. PF-07304814

PF-07304814 

Cat. No.: HY-138078
Handling Instructions

PF-07304814, a phosphate prodrug of PF-00835231, acts as a potent 3CLpro protease (Mpro) inhibitor with SARS-CoV-2 antiviral activity. PF-07304814 binds and inhibits SARS-CoV-2 3CLpro activity with a Ki of 174nM. PF-07304814 is promising single antiviral agent and also can be used for the research of combination with other antivirals that target other critical stages of the coronavirus life cycle.

For research use only. We do not sell to patients.

PF-07304814 Chemical Structure

PF-07304814 Chemical Structure

CAS No. : 2468015-78-1

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Description

PF-07304814, a phosphate prodrug of PF-00835231, acts as a potent 3CLpro protease (Mpro) inhibitor with SARS-CoV-2 antiviral activity. PF-07304814 binds and inhibits SARS-CoV-2 3CLpro activity with a Ki of 174nM. PF-07304814 is promising single antiviral agent and also can be used for the research of combination with other antivirals that target other critical stages of the coronavirus life cycle[1].

In Vivo

Once administered through intravenous infusion, PF-07304814 is cleaved into PF-00835231 to exert its anti-viral effects. PF-07304814 exhibits a favorable cardiovascular safety profile[1].
PF-07304814 is administered intravenously to rats, dogs and monkeys. It exhibits high systemic clearance and short half-life across species forming 68, 81, 76% PF-00835231 in rats, dogs and monkey respectively in comparison to the systemic exposure achieved with IV administration of PF00835231[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

552.51

Formula

C₂₄H₃₃N₄O₉P

CAS No.
SMILES

COC1=C(C=C2C(N[[email protected]@H](CC(C)C)C(N[[email protected]](C(CO[P](O)(O)=O)=O)C[[email protected]](CCN3)C3=O)=O)=O)C(N2)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PF-07304814PF07304814PF 07304814SARS-CoVSARS coronavirusCOVID-19 infection3CLpro;?proteaseMproSARS-CoV-2virusCoronavirusInhibitorinhibitorinhibit

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PF-07304814
Cat. No.:
HY-138078
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