1. Anti-infection
  2. SARS-CoV
  3. PLpro inhibitor

PLpro inhibitor 

Cat. No.: HY-17542
Handling Instructions

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM.

For research use only. We do not sell to patients.

PLpro inhibitor Chemical Structure

PLpro inhibitor Chemical Structure

CAS No. : 1093070-14-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 uM. IC50 Value: 2.6 uM [1] Target: PLpro; SARS-CoV in vitro: PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 ± 0.1 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1±0.7 uM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells [1,2]. in vivo:

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 42 mg/mL (121.24 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8867 mL 14.4333 mL 28.8667 mL
5 mM 0.5773 mL 2.8867 mL 5.7733 mL
10 mM 0.2887 mL 1.4433 mL 2.8867 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

346.42

Formula

C₂₂H₂₂N₂O₂

CAS No.

1093070-14-4

SMILES

O=C(C1=CC(NC(C)=O)=CC=C1C)N[[email protected]](C)C2=C(C=CC=C3)C3=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
PLpro inhibitor
Cat. No.:
HY-17542
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PLpro inhibitor

Cat. No.: HY-17542