1. Protein Tyrosine Kinase/RTK
  2. Pyk2
  3. PF-4618433

PF-4618433 

Cat. No.: HY-18312
Handling Instructions

PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration.

For research use only. We do not sell to patients.

PF-4618433 Chemical Structure

PF-4618433 Chemical Structure

CAS No. : 1166393-85-6

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Description

PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration[1][2].

IC50 & Target

IC50: 637 nM (PYK2)[1]

In Vitro

PF-4618433 (0.1-1.0 μM; 7 days) promotes osteogenesis of hMSC cultures. PF-4618433 increases in both alkaline phosphatase (ALP) activity and mineralization in a dependent manner[1].
PF-4618433 (0.1-0.3 μM; 24 hours) enhances osteoblast proliferation[2].
PF-4618433 (0.0125-0.3 μM; 14 or 21 days) enhances calcium deposition at the concentrations of 0.1 and 0.3 μM[2].

Cell Proliferation Assay[2]

Cell Line: Murine bone marrow-derived mesenchymal stem cells (BMSC)
Concentration: 0.1, 0.3 μM
Incubation Time: 24 hours
Result: Increased cell proliferation activity significantly when compared to the untreated or control group.
Molecular Weight

445.52

Formula

C₂₄H₂₇N₇O₂

CAS No.

1166393-85-6

SMILES

O=C(NC1=CC(COC2=CC=CN=C2)=NN1)NC3=CC(C(C)(C)C)=NN3C4=CC=C(C)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PF-4618433PF4618433PF 4618433Pyk2Proline-rich tyrosine kinase 2PYK2osteoporosisBMSChMSCalkalinephosphataseALPInhibitorinhibitorinhibit

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PF-4618433
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