Pronethalol hydrochloride (Synonyms: (±)-Pronethalo hydrochloride)

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Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs).

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Pronethalol hydrochloride Chemical Structure

CAS No. : 51-02-5

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Other In-stock Forms of Pronethalol hydrochloride:

Pronethalol

Other Forms of Pronethalol hydrochloride:

Pronethalol In-stock

1 Publications Citing Use of MCE Pronethalol hydrochloride

•Int J Biol Macromol. 2023 May 19;242(Pt 2):124870. [Abstract]

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Description	Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)^[1]^[2].
In Vitro	Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces Sox2 expression to less than 10% after 2 days of treatment^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Pronethalol hydrochloride Related Antibodies
In Vivo	Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp^–/– mice^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	265.78
Formula	C₁₅H₂₀ClNO
CAS No.	51-02-5
SMILES	OC(CNC(C)C)C1=CC=C2C=CC=CC2=C1.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pronethalol51-02-5(±)-PronethaloInhibitorinhibitorinhibit

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