1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Pronethalol hydrochloride

Pronethalol hydrochloride (Synonyms: (±)-Pronethalo hydrochloride)

Cat. No.: HY-B1238A
Handling Instructions

Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protect against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs).

For research use only. We do not sell to patients.

Pronethalol hydrochloride Chemical Structure

Pronethalol hydrochloride Chemical Structure

CAS No. : 51-02-5

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Description

Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protect against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs)[1][2].

In Vitro

Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces Sox2 expression to less than 10% after 2 days of treatment[2].

In Vivo

Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp–/– mice[2].

Molecular Weight

265.78

Formula

C₁₅H₂₀ClNO

CAS No.

51-02-5

SMILES

OC(CNC(C)C)C1=CC=C2C=CC=CC2=C1.Cl

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Pronethalol(±)-PronethaloAdrenergic ReceptorBeta ReceptorSox2expressionDigitalisventriculararrhythmiascerebralarteriovenousmalformationAVMsEGFPendothelialdifferentiationlumenformationInhibitorinhibitorinhibit

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Pronethalol hydrochloride
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HY-B1238A
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