51-02-5
51-02-5
Chemical Structure
Pronethalol hydrochloride
Synonym(s): (±)-Pronethalo hydrochloride
- CAS. Nr.: 51-02-5
- Formula:C15H20ClNO
- Molecular Weight:265.78
IUPAC Name: 2-(isopropylamino)-1-(naphthalen-2-yl)ethan-1-ol hydrochloride
InChIKey: QONLGXRPRAIDGI-UHFFFAOYSA-N
SMILES: OC(CNC(C)C)C1=CC=C2C=CC=CC2=C1.Cl
Biological Activity: Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2].
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Pronethalol hydrochloride | Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs). | |||||||||||||||||||||
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References
- [1]. Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-8. [Content Brief]
- [2]. Jiayi Yao, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019 Jun 24;129(8):3121-3133. [Content Brief]
