2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. LAIR-1

LAIR-1

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Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1), also known as CD305, is a transmembrane glycoprotein inhibitory receptor characterized by an extracellular C2-type Ig-like domain and two ITIMs in the cytoplasmic tail. It is expressed not only on NK cells but also on other cells of innate immunity (such as monocytes, granulocytes, dendritic cells, mast cells, macrophages), on T and B lymphocytes, on CD34+ hematopoietic progenitor cells and on the majority of thymocytes. During the process of cell maturation and activation, LAIR-1 expression is decreased on various immune cells (i.e., CD4+ T cells, neutrophils, B cells). The interaction between LAIR-1 and its several ligands, such as extracellular matrix collagens, the C1q complement component, and the surfactant protein D, induces phosphorylation of both ITIMs and inhibition of the immune cell activation or differentiation. LAIR-1 plays a role in controlling various phases of the immune response and is considered to be an immune checkpoint in different inflammatory diseases.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70871
    LAIR1 Protein, Mouse (HEK293, His)

    Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; mLAIR-1; CD305; Lair1

    		Mouse HEK293
    The LAIR1 protein functions as an inhibitory receptor that negatively regulates NK cells, B cells, and T cells. LAIR1 is activated by tyrosine phosphorylation, recruits PTPN6 and PTPN11, and exerts downstream inhibitory effects. LAIR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LAIR1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LAIR1 Protein, Mouse (HEK293, His) is 120 a.a., with molecular weight of 21-35 kDa.
  • HY-P78476
    LAIR1 Protein, Human (HEK293, His-Avi)

    CD305; HLAIR1; LAIR1; LAIR-1

    		Human HEK293
    LAIR1 protein has a negative regulatory effect on NK cells, B cells and T cells. It activates the phosphatases PTPN6 and PTPN11, inhibits calcium increases in B cells, and regulates cytokine production in CD4+ T cells. LAIR1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived LAIR1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of LAIR1 Protein, Human (HEK293, His-Avi) is 142 a.a., with molecular weight of 30-36 kDa.
  • HY-P72390
    LAIR1 Protein, Human (Biotinylated, HEK293, Avi-His)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305; LAIR1

    		Human HEK293
    LAIR1 protein has a negative regulatory effect on NK cells, B cells and T cells. It activates the phosphatases PTPN6 and PTPN11, inhibits calcium increases in B cells, and regulates cytokine production in CD4+ T cells. LAIR1 Protein, Human (Biotinylated, HEK293, Avi-His) is the recombinant human-derived LAIR1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of LAIR1 Protein, Human (Biotinylated, HEK293, Avi-His) is 142 a.a., with molecular weight of 30-35 kDa.
  • HY-P72529
    LAIR1 Protein, Human (HEK293, His)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305

    		Human HEK293
    LAIR1 protein has a negative regulatory effect on NK cells, B cells and T cells. It activates the phosphatases PTPN6 and PTPN11, inhibits calcium increases in B cells, and regulates cytokine production in CD4+ T cells. LAIR1 Protein, Human (HEK293, His) is the recombinant human-derived LAIR1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LAIR1 Protein, Human (HEK293, His) is 142 a.a., with molecular weight of ~28 kDa.
  • HY-P74783
    LAIR1 Protein, Mouse (HEK293, Fc)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305

    		Mouse HEK293
    The LAIR1 protein functions as an inhibitory receptor, negatively regulating NK cells, B-cells, and T-cells. Activated by tyrosine phosphorylation, LAIR1 recruits PTPN6 and PTPN11, exerting downstream inhibitory effects. It diminishes intracellular calcium increase triggered by B-cell receptor ligation and independently modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG while inducing TGF-beta secretion. LAIR1 also regulates IgG and IgE production, inhibits proliferation, induces apoptosis in myeloid leukemia cells, prevents NF-kappa-B p65 subunit translocation, and inhibits I-kappa-B alpha phosphorylation. LAIR1 associates with SH2 domains of PTPN6 and PTPN11 and binds with high affinity to extracellular matrix collagens, signifying a functionally significant interaction. LAIR1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived LAIR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LAIR1 Protein, Mouse (HEK293, Fc) is 112 a.a., with molecular weight of 49-53 kDa.
  • HY-P74784
    LAIR1 Protein, Human (144a.a, HEK293, hFc)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305

    		Human HEK293
    LAIR1 protein has a negative regulatory effect on NK cells, B cells and T cells. It activates the phosphatases PTPN6 and PTPN11, inhibits calcium increases in B cells, and regulates cytokine production in CD4+ T cells. LAIR1 Protein, Human (144a.a, HEK293, hFc) is the recombinant human-derived LAIR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LAIR1 Protein, Human (144a.a, HEK293, hFc) is 144 a.a., with molecular weight of ~42.8 kDa.
  • HY-P74786
    LAIR1 Protein, Human (Biotinylated, 144a.a, HEK293, His)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305

    		Human HEK293
    LAIR1 protein has a negative regulatory effect on NK cells, B cells and T cells. It activates the phosphatases PTPN6 and PTPN11, inhibits calcium increases in B cells, and regulates cytokine production in CD4+ T cells. LAIR1 Protein, Human (Biotinylated, 144a.a, HEK293, His) is the recombinant human-derived LAIR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of LAIR1 Protein, Human (Biotinylated, 144a.a, HEK293, His) is 144 a.a., with molecular weight of ~17.2 kDa.
  • HY-P72528
    LAIR1 Protein, Rhesus Macaque (HEK293, His)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305

    		Rhesus Macaque HEK293
    LAIR1 Protein is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. LAIR1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived LAIR1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LAIR1 Protein, Rhesus Macaque (HEK293, His) is 144 a.a., with molecular weight of 25-33 kDa.
Cat. No. Product Name Effect Purity