1. GPCR/G Protein
  2. LPL Receptor
  3. S1P1 agonist 5

S1P1 agonist 5 

Cat. No.: HY-144126
Handling Instructions

S1P1 agonist 5 is a selective and orally active S1P1 agonist. S1P1 agonist 5 inhibits the lymphocyte egress from the lymphoid tissue to the peripheral blood. S1P1 agonist 5 has the potential for the research of multiple sclerosis (MS).

For research use only. We do not sell to patients.

S1P1 agonist 5 Chemical Structure

S1P1 agonist 5 Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All LPL Receptor Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

S1P1 agonist 5 is a selective and orally active S1P1 agonist. S1P1 agonist 5 inhibits the lymphocyte egress from the lymphoid tissue to the peripheral blood. S1P1 agonist 5 has the potential for the research of multiple sclerosis (MS)[1].

In Vitro

S1P1 agonist 5 (compound 21l) shows excellent in vitro efficacies with EC50s of 7.03 nM and 11.8 nM for β-arrestin recruitment and internalization, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

S1P1 agonist 5 shows good oral bioavaliabily in rats (F=54.2%) and dogs (F=31.8%)[1].
S1P1 agonist 5 (10 mg/kg; p.o.) inhibits the lymphocyte egress from the lymphoid tissue to the peripheral blood and that lymphopenia can be recovered within 24 hours[1].
S1P1 agonist 5 (3, 10 mg/kg, p.o., once daily for 20 days) ameliorates the disease progression and overall severity in EAE mice, showing favorable drug-like properties[1].
Pharmacokinetic Parameters of S1P1 in rats, male beagle dogs[1].

administration parameters rat dog
i.v. T1/2 (h) 1.4±0.3 5.70±1.2
AUC0-∞ (ng*h/mL) 931.3±95.7 14,830.8±5475.4
CL (mL/min/kg) 17.6±2.0 149.9±62.5
Vss (L/kg) 1.7±0.2 828.7±134.2
p.o. Cmax (ng/mL) 1661.1±916.6 3979.4±483.5
Tmax(h) 0.9±0.8 1.3±0.5
T1/2 (h) 1.4±0.2 4.9±0.6
AUC0-∞ (ng*h/mL) 5044.9±1061 23,109.9±7752.2
F (%) 54.2 31.8
Rats, 1 mg/kg for i.v.; 10 mg/kg for p.o.. dogs, 2 mg/kg i.v.;10 mg/kg for p.o.[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: rats, male beagle dogs[1]
Dosage:
Administration: 1 mg/kg for i.v. and 10 mg/kg for p.o (rats); 2 mg/kg for i.v. and 10 mg/kg for p.o.(dogs)
Result: Showed good oral bioavaliabily in rats (F=54.2%) and dogs (F=31.8%).
Animal Model: male wistar rats (5 week, 160-180 g)[1]
Dosage: 10 mg/kg
Administration: p.o.
Result: Inhibited the lymphocyte egress from the lymphoid tissue to the peripheral blood and that lymphopenia can be recovered within 24 hours.
Animal Model: female C57BL/6 mice (10 weeks,19−22 g) (experimental autoimmune encephalitis (EAE) mouse model)[1]
Dosage: 3, 10 mg/kg (dissolved in 2.5% DMSO and 5% Kolliphor HS 15 (Sigma-Aldrich) in distilled water)
Administration: p.o., once daily, 20 days
Result: Ameliorated the disease progression and overall severity in EAE mice, showing favorable drug-like properties.
Molecular Weight

450.89

Formula

C23H24ClN2NaO4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
S1P1 agonist 5
Cat. No.:
HY-144126
Quantity:
MCE Japan Authorized Agent: