2. GPCR/G Protein
  3. LPL Receptor
  4. S1P1 agonist 5

S1P1 agonist 5 is a selective and orally active S1P1 agonist. S1P1 agonist 5 inhibits the lymphocyte egress from the lymphoid tissue to the peripheral blood. S1P1 agonist 5 has the potential for the research of multiple sclerosis (MS).

For research use only. We do not sell to patients.

S1P1 agonist 5 Chemical Structure

S1P1 agonist 5 Chemical Structure

CAS No. : 2760666-20-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

S1P1 agonist 5 Related Antibodies

Top Publications Citing Use of Products

View All LPL Receptor Isoform Specific Products:

View All Isoforms
LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

S1P1 agonist 5 is a selective and orally active S1P1 agonist. S1P1 agonist 5 inhibits the lymphocyte egress from the lymphoid tissue to the peripheral blood. S1P1 agonist 5 has the potential for the research of multiple sclerosis (MS)[1].

In Vitro

S1P1 agonist 5 (compound 21l) shows excellent in vitro efficacies with EC50s of 7.03 nM and 11.8 nM for β-arrestin recruitment and internalization, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S1P1 agonist 5 Related Antibodies
In Vivo

S1P1 agonist 5 shows good oral bioavaliabily in rats (F=54.2%) and dogs (F=31.8%)[1].
S1P1 agonist 5 (10 mg/kg; p.o.) inhibits the lymphocyte egress from the lymphoid tissue to the peripheral blood and that lymphopenia can be recovered within 24 hours[1].
S1P1 agonist 5 (3, 10 mg/kg, p.o., once daily for 20 days) ameliorates the disease progression and overall severity in EAE mice, showing favorable drug-like properties[1].
Pharmacokinetic Parameters of S1P1 in rats, male beagle dogs[1].

administration parameters rat dog
i.v. T1/2 (h) 1.4±0.3 5.70±1.2
AUC0-∞ (ng*h/mL) 931.3±95.7 14,830.8±5475.4
CL (mL/min/kg) 17.6±2.0 149.9±62.5
Vss (L/kg) 1.7±0.2 828.7±134.2
p.o. Cmax (ng/mL) 1661.1±916.6 3979.4±483.5
Tmax(h) 0.9±0.8 1.3±0.5
T1/2 (h) 1.4±0.2 4.9±0.6
AUC0-∞ (ng*h/mL) 5044.9±1061 23,109.9±7752.2
F (%) 54.2 31.8
Rats, 1 mg/kg for i.v.; 10 mg/kg for p.o.. dogs, 2 mg/kg i.v.;10 mg/kg for p.o.[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: rats, male beagle dogs[1]
Dosage:
Administration: 1 mg/kg for i.v. and 10 mg/kg for p.o (rats); 2 mg/kg for i.v. and 10 mg/kg for p.o.(dogs)
Result: Showed good oral bioavaliabily in rats (F=54.2%) and dogs (F=31.8%).
Animal Model: male wistar rats (5 week, 160-180 g)[1]
Dosage: 10 mg/kg
Administration: p.o.
Result: Inhibited the lymphocyte egress from the lymphoid tissue to the peripheral blood and that lymphopenia can be recovered within 24 hours.
Animal Model: female C57BL/6 mice (10 weeks,19−22 g) (experimental autoimmune encephalitis (EAE) mouse model)[1]
Dosage: 3, 10 mg/kg (dissolved in 2.5% DMSO and 5% Kolliphor HS 15 (Sigma-Aldrich) in distilled water)
Administration: p.o., once daily, 20 days
Result: Ameliorated the disease progression and overall severity in EAE mice, showing favorable drug-like properties.
Molecular Weight

450.89

Formula

C23H24ClN2NaO4
CAS No.
SMILES

O=C(C1CN(CC2=CC=C(C=C2)C3=NOC(C3)C4=CC(Cl)=C(C=C4)OC(C)C)C1)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

S1P1 agonist 5 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S1P1 agonist 52760666-20-2LPL ReceptorLysophospholipid Receptororally activemultiple sclerosis (MS)selectivelymphocyteautoimmune encephalitis (EAE) mouse modeldrug-likeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
S1P1 agonist 5
Cat. No.:
HY-144126
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.