2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Sameridine

Sameridine (NIH-10908 free base) is a weak partial agonist of the μ-opioid receptor. Sameridine shows local anesthetic and analgesic properties. Sameridine has minimal respiratory depression at low doses, but can suppress ventilatory response at high doses. Sameridine can be used for the study of analgesic effect.

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Sameridine

Sameridine Chemical Structure

CAS No. : 143257-97-0

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Sameridine Related Antibodies

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Description

Sameridine (NIH-10908 free base) is a weak partial agonist of the μ-opioid receptor. Sameridine shows local anesthetic and analgesic properties. Sameridine has minimal respiratory depression at low doses, but can suppress ventilatory response at high doses. Sameridine can be used for the study of analgesic effect[1][2].

IC50 & Target

μ Opioid Receptor/MOR

 

In Vivo

Sameridine (5-10 mg/mL, intrathecal injection, twice daily, five days a week, for two weeks) did not induce significant neurotoxicity in a rat model after intrathecal injection[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (weighing 320-420 g)[1].
Dosage: 5 mg/mL (10 μL), 10 mg/mL (10 μL)
Administration: Intrathecal injection, twice daily, five days a week, for two weeks.
Result: No permanent motor impairment was observed in any group.
The dorsal horn neurons in the L1 segment of the spinal cord showed normal morphology, and no signs of neurotoxicity were found, such as edema, organelle damage, necrosis, or microglia.
Molecular Weight

330.51

Formula

C21H34N2O
CAS No.
SMILES

O=C(C1(CCN(CC1)CCCCCC)C2=CC=CC=C2)N(CC)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sameridine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sameridine143257-97-0NIH 10908NIH10908NIH-10908Opioid Receptorμ-opioid partial agonistLocal anesthetic activityInhibitorinhibitorinhibit

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