143257-97-0
Chemical Structure
Sameridine
Synonym(s): NIH 10908 free base
- CAS No.: 143257-97-0
- Formula:C21H34N2O
- Molecular Weight:330.51
IUPAC Name: N-ethyl-1-hexyl-N-methyl-4-phenylpiperidine-4-carboxamide
InChIKey: TYWUGCGYWNSRPS-UHFFFAOYSA-N
SMILES: O=C(C1(CCN(CC1)CCCCCC)C2=CC=CC=C2)N(CC)C
Biological Activity: Sameridine (NIH-10908 free base) is a weak partial agonist of the μ-opioid receptor. Sameridine shows local anesthetic and analgesic properties. Sameridine has minimal respiratory depression at low doses, but can suppress ventilatory response at high doses. Sameridine can be used for the study of analgesic effect[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Sameridine | Sameridine (NIH-10908 free base) is a weak partial agonist of the μ-opioid receptor. Sameridine shows local anesthetic and analgesic properties. Sameridine has minimal respiratory depression at low doses, but can suppress ventilatory response at high doses. Sameridine can be used for the study of analgesic effect. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Mulroy MF, et al. Sameridine is safe and effective for spinal anesthesia: a comparative dose-ranging study with lidocaine for inguinal hernia repair. Anesth Analg. 1999 Apr;88(4):815-21. [Content Brief]
- [2]. Osterlund A, et al. The effects on resting ventilation of intravenous infusions of morphine or sameridine, a novel molecule with both local anesthetic and opioid properties. Anesth Analg. 1999 Jan;88(1):160-5. [Content Brief]
Keywords
