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  4. Sanggenol F

Sanggenol F is a natural phenolic compound.

For research use only. We do not sell to patients.

Sanggenol F

Sanggenol F Chemical Structure

CAS No. : 202526-51-0

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Sanggenol F Related Antibodies

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Description

Sanggenol F is a natural phenolic compound.

IC50 & Target[1]

α‑glucosidase

12.39 μM (IC50)

PPARγ

 

In Vitro

Sanggenol F (2.5-10 μM; 8 days) promotes adipocyte differentiation in 3T3-L1 preadipocytes[1].
Sanggenol F (1.25-10 μM; 8 days) enhances glucose uptake in differentiated 3T3-L1 adipocytes[1].
Sanggenol F (10 μM; 0-8 h) stimulates P-AKT expression in mature 3T3-L1 adipocytes[1].
Sanggenol F (0.625-30 μM; 18-24 h) activates PPARγ transcriptional activity in HEK293T cells[1][2].
Sanggenol F (1.25-20 μM; 30 min) inhibits PTP1B activity in a concentration-dependent manner[1].
Sanggenol F (2.5-10 μM; 1-8 days) modulates adipokine and lipogenic gene expression in 3T3-L1 cells[1].
Sanggenol F inhibit α-glucosidase with an IC50 of 12.39 μM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sanggenol F Related Antibodies

Western Blot Analysis[1]

Cell Line: Mature 3T3-L1 adipocytes
Concentration: 10 μM
Incubation Time: 0, 2, 5, 10, 30 min, 1, 2, 4, 8 h
Result: Stimulated P-AKT expression over the indicated time points

Real Time qPCR[1]

Cell Line: 3T3-L1 cells
Concentration: 2.5, 5, 10 μM
Incubation Time: 1-8 days
Result: Upregulated mRNA levels of adiponectin, visfatin, SREBP1c, ACC1, FAS, GPAT, DGAT1, DGAT2.
Downregulated MCP1 mRNA.
Upregulated C/EBPβ and PPARγ mRNA over Days 1-3 at 2.5 and 5 μM.
In Vivo

Sanggenol F (8-30 mg/kg; i.p.; daily; 28 days) improves glucose metabolism, insulin sensitivity, lipid metabolism, and hepatic steatosis in male C57BL/KsJ-db/db mice with type 2 diabetes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/KsJ-db/db (male, 6-week-old)[1]
Dosage: 8, 30 mg/kg
Administration: i.p.; daily; 28 days
Result: Decreased fasting blood glucose and serum insulin content.
Improved glucose tolerance with reduced OGTT AUC and improved insulin sensitivity with reduced ITT AUC.
Decreased serum triglyceride and free fatty acid levels.
Upregulated lipogenic genes (ACC1, FAS, GLUT4, PPARγ) in epididymal white adipose tissue and inguinal white adipose tissue.
Downregulated inflammatory adipokines (MCP1, IL-6, IL-1β) and monocyte/macrophage markers (CD11b, CD11c, F4/80) in epididymal white adipose tissue and inguinal white adipose tissue.
Upregulated adiponectin in epididymal white adipose tissue and inguinal white adipose tissue.
Increased hepatic p-AKT expression.
Suppressed hepatic gluconeogenic genes (G6PC, PCK1) and glycogenolytic gene (PYGL).
Reduced hepatic triglyceride content and ameliorated hepatic steatosis.
Molecular Weight

438.47

Formula

C25H26O7
CAS No.
SMILES

C/C(C)=C\C[C@@]12[C@@](C(C3=C(O)C(C/C=C(C)\C)=C(O)C=C3O1)=O)(OC4=CC(O)=CC=C42)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sanggenol F Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sanggenol F202526-51-0Drug DerivativeDrug derivativeinsulinPPARγsteatosis3T3-L1 adipocytesPPARαC57BL/KsJ-db/db miceadipokinelipid levelstype 2 diabetesP-AKTPTP1Bfasting blood glucoseHEK293T cellsInhibitorinhibitorinhibit

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