Sanggenol F
Sanggenol F is a natural phenolic compound.
For research use only. We do not sell to patients.
- CAS No.: 202526-51-0
- Formula: C25H26O7
- Molecular Weight:438.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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α‑glucosidase 12.39 μM (IC50) |
PPARγ |
Sanggenol F (2.5-10 μM; 8 days) promotes adipocyte differentiation in 3T3-L1 preadipocytes[1].
Sanggenol F (1.25-10 μM; 8 days) enhances glucose uptake in differentiated 3T3-L1 adipocytes[1].
Sanggenol F (10 μM; 0-8 h) stimulates P-AKT expression in mature 3T3-L1 adipocytes[1].
Sanggenol F (0.625-30 μM; 18-24 h) activates PPARγ transcriptional activity in HEK293T cells[1][2].
Sanggenol F (1.25-20 μM; 30 min) inhibits PTP1B activity in a concentration-dependent manner[1].
Sanggenol F (2.5-10 μM; 1-8 days) modulates adipokine and lipogenic gene expression in 3T3-L1 cells[1].
Sanggenol F inhibit α-glucosidase with an IC50 of 12.39 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mature 3T3-L1 adipocytes
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Concentration:10 μM
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Incubation Time:0, 2, 5, 10, 30 min, 1, 2, 4, 8 h
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Result:Stimulated P-AKT expression over the indicated time points
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Cell Line:3T3-L1 cells
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Concentration:2.5, 5, 10 μM
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Incubation Time:1-8 days
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Result:Upregulated mRNA levels of adiponectin, visfatin, SREBP1c, ACC1, FAS, GPAT, DGAT1, DGAT2.
Downregulated MCP1 mRNA.
Upregulated C/EBPβ and PPARγ mRNA over Days 1-3 at 2.5 and 5 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/KsJ-db/db (male, 6-week-old)[1]
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Dosage:8, 30 mg/kg
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Administration:i.p.; daily; 28 days
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Result:Decreased fasting blood glucose and serum insulin content.
Improved glucose tolerance with reduced OGTT AUC and improved insulin sensitivity with reduced ITT AUC.
Decreased serum triglyceride and free fatty acid levels.
Upregulated lipogenic genes (ACC1, FAS, GLUT4, PPARγ) in epididymal white adipose tissue and inguinal white adipose tissue.
Downregulated inflammatory adipokines (MCP1, IL-6, IL-1β) and monocyte/macrophage markers (CD11b, CD11c, F4/80) in epididymal white adipose tissue and inguinal white adipose tissue.
Upregulated adiponectin in epididymal white adipose tissue and inguinal white adipose tissue.
Increased hepatic p-AKT expression.
Suppressed hepatic gluconeogenic genes (G6PC, PCK1) and glycogenolytic gene (PYGL).
Reduced hepatic triglyceride content and ameliorated hepatic steatosis.
Chemical Information
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CAS No. 202526-51-0
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Molecular Weight 438.47
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Formula C25H26O7
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SMILES
C/C(C)=C\C[C@@]12[C@@](C(C3=C(O)C(C/C=C(C)\C)=C(O)C=C3O1)=O)(OC4=CC(O)=CC=C42)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Xu L, et al. Phenolic compounds isolated from Morus nigra and their α-glucosidase inhibitory activities. Nat Prod Res. 2020 Mar;34(5):605-612. [Content Brief]
[2]. Zhu JJ, et al. Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression. Endocrine. 2017;56(1):73-81. [Content Brief]
[3]. Xu LJ, et al. Isoprenylated flavonoids from Morus nigra and their PPAR γ agonistic activities. Fitoterapia. 2018;127:109-114. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sanggenol F Related Classifications
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