3 Results for "

FASN-IN-2

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "FASN-IN-2" in MCE Product Catalog:

8
Denifanstat
Denifanstat
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8 Cited Publications
Cat. No.: HY-112829
CAS No.: 1399177-37-7
Purity:  99.58%
Synonyms: TVB-2640; FASN-IN-2; ASC-40
Target:  

Fatty Acid Synthase (FASN)

Research Areas:  

Metabolic Disease Cancer

Denifanstat (TVB-2640) is an orally active and potent Fatty Acid Synthase (FASN) inhibitor with an IC50 of 0.052 μM and an EC50 of 0.072 μM. Denifanstat has the potential for fatty liver disease and cancer research [2].
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Monascuspiloin
Monascuspiloin
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Cat. No.: HY-N12124
CAS No.: 1011244-19-1
Synonyms: MonascINol
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Fatty Acid Synthase (FASN) Akt mTOR AMPK Androgen Receptor Caspase Apoptosis Autophagy

Monascuspiloin (Monascinol) is an orally active compound extracted from red mold-fermented rice, with multiple biological activities including anti-androgenic, anti-inflammatory, hypolipidemic, and anti-cancer properties. Monascuspiloin attenuates the PI3K/Akt/mTOR signaling pathway, enhances AMPK phosphorylation, downregulates FASN/SREBP2, induces apoptosis, G2/M phase arrest and autophagy in prostate cancer cells, interferes with dihydrotestosterone-receptor binding, enhances radiation-induced DNA damage, stimulates endoplasmic reticulum stress, and alleviates hepatic oxidative stress. Monascuspiloin regulates hepatic metabolic pathways and modulates the expression of genes and proteins related to hepatic lipid metabolism. Monascuspiloin can be used in studies related to prostate cancer and alcoholic liver injury [2] .
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Floramanoside F
Floramanoside F
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Cat. No.: HY-N17737
CAS No.: 1487423-58-4
Category:  

Malvaceae Flavonols Flavonoids Abelmoschus manihot (Linn.) Medicus Plants

Target:  

Fatty Acid Synthase (FASN) Cytochrome P450

Floramanoside F is a type of flavonol glycoside compound. Floramanoside F has a moderate free radical scavenging effect, with a SC₅₀ value of 25.1 μM. Floramanoside F has a relatively weak inhibitory activity on aldose reductase, with a IC₅₀ value greater than 100 μM. Floramanoside F has strong binding affinity with key target enzymes of type 1 diabetic nephropathy (T1DN) (Fasn, Cyp2e1, Cyp4a32), and can inhibit lipid accumulation and oxidative stress, thereby alleviating renal inflammation and fibrosis. Floramanoside F can be used to study type 1 diabetic nephropathy and diabetic complications [2].
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