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147331-98-4

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1 Results for "147331-98-4" in MCE Product Catalog:

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Plantainoside D
Plantainoside D
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Cat. No.: HY-N5063
CAS No.: 147331-98-4
Category:  

Cardiovascular Disease Simple Phenylpropanols Scrophulariaceae Phenols Polyphenols Phenylpropanoids Plants Picrorhiza scrophulariiflora Pennell Disease Research Fields

Target:  

Angiotensin-converting Enzyme (ACE) IKK Calcium Channel PKC Reactive Oxygen Species (ROS) NF-κB Apoptosis Sirtuin NOD-like Receptor (NLR)

Plantainoside D, a phenylethanoid glycosides, is a IKK-β inhibitor with diverse biological activities. Plantainoside D shows inhibitory activity of angiotensin-converting enzyme (ACE) with an IC50 of 2.17 mM. Plantainoside D significantly reduces the release of glutamate from nerve terminals in the cerebral cortex of rats by inhibiting the voltage-dependent calcium channel (VDCCs) and protein kinase C (PKC) signaling cascade. Plantainoside D significantly alleviates cell apoptosis by inhibiting the generation of ROS and the activation of NF-κB. Plantainoside D significantly improves acute lung injury (ALI) induced by sepsis by regulating the Sirt3/NLRP3 signaling pathway. Plantainoside D can be used for the study of neuroprotection, antioxidant, anti-inflammation, antihypertension .
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