147331-98-4
Chemical Structure
Plantainoside D
- CAS 番号: 147331-98-4
- Formula:C29H36O16
- Molecular Weight:640.59
IUPAC Name: ((2R,3R,4S,5R,6R)-6-(3,4-dihydroxyphenethoxy)-3,5-dihydroxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl (E)-3-(3,4-dihydroxyphenyl)acrylate
InChIKey: CBZYUWGJNYOKHT-ZKDZFUIGSA-N
SMILES: O[C@H]([C@H]([C@@H]([C@@H](COC(/C=C/C1=CC=C(O)C(O)=C1)=O)O2)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)[C@@H]2OCCC4=CC=C(O)C(O)=C4
Biological Activity: Plantainoside D, a phenylethanoid glycosides, is a IKK-β inhibitor with diverse biological activities. Plantainoside D shows inhibitory activity of angiotensin-converting enzyme (ACE) with an IC50 of 2.17 mM. Plantainoside D significantly reduces the release of glutamate from nerve terminals in the cerebral cortex of rats by inhibiting the voltage-dependent calcium channel (VDCCs) and protein kinase C (PKC) signaling cascade. Plantainoside D significantly alleviates cell apoptosis by inhibiting the generation of ROS and the activation of NF-κB. Plantainoside D significantly improves acute lung injury (ALI) induced by sepsis by regulating the Sirt3/NLRP3 signaling pathway. Plantainoside D can be used for the study of neuroprotection, antioxidant, anti-inflammation, antihypertension[1][2][3][4][5][6].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Plantainoside D | 99.15% | Plantainoside D, a phenylethanoid glycosides, is a IKK-β inhibitor with diverse biological activities. Plantainoside D shows inhibitory activity of angiotensin-converting enzyme (ACE) with an IC50 of 2.17 mM. Plantainoside D significantly reduces the release of glutamate from nerve terminals in the cerebral cortex of rats by inhibiting the voltage-dependent calcium channel (VDCCs) and protein kinase C (PKC) signaling cascade. Plantainoside D significantly alleviates cell apoptosis by inhibiting the generation of ROS and the activation of NF-κB. Plantainoside D significantly improves acute lung injury (ALI) induced by sepsis by regulating the Sirt3/NLRP3 signaling pathway. Plantainoside D can be used for the study of neuroprotection, antioxidant, anti-inflammation, antihypertension. | ||||||||||||||||||||
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Verbascoside | 99.83% | Verbascoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 μM, and has antitumor, anti-inflammatory and antineuropathic pain activity. | ||||||||||||||||||||
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Isoacteoside (Standard) | ≥98% | Isoacteoside (Standard) is the analytical standard of Isoacteoside. This product is intended for research and analytical applications. Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside Standard regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside Standard exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities. | ||||||||||||||||||||
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Plantamajoside | 99.80% | Plantamajoside is an orally active phenylpropanoid glycoside. Plantamajoside can be isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside inactivates NF-κB, PI3K/akt, induces Apoptosis, and improves Autophagy. Plantamajoside regulates MAPK, integrin-linked kinase/c-Src. Plantamajoside inhibits multiple cancers, improves lung and kidney damage. Plantamajoside has neuroprotective and anti-inflammatory effects. | ||||||||||||||||||||
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Isolugrandoside | 98.28% | Isolugrandoside is a nature product. Isolugrandoside can be isolated from Digitalis davisiana Heywood. | ||||||||||||||||||||
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Lugrandoside | Lugrandoside is a nature product. Lugrandoside can be isolated from Digitalis davisiana Heywood. | |||||||||||||||||||||
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cis-Verbascoside | cis-Verbascoside (cis-Acteoside) is a phenylethanoid that can be found in Blepharis edulis. | |||||||||||||||||||||
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Plantainoside E | Plantainoside E is a phenylpropanoid glycoside. Plantainoside E can be isolated from the leaves of Plantago major L. Plantainoside E shows no angiotensin-converting enzyme inhibitory activity. Plantainoside E can be used in hypertension research. | |||||||||||||||||||||
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Isocistanoside C | Isocistanoside C is a phenylethanoid glycoside that can be isolated from Cistanche deserticola. Isocistanoside C exhibits antioxidant activity and inhibits the production of NO. | |||||||||||||||||||||
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Magnoloside A | 98.16% | Magnoloside A (compound 4) is a main phenylethanoid glycoside in Houpo. Magnoloside A can be used in the research of functional dyspepsia (FD). | ||||||||||||||||||||
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Hemiphroside B | 97.83% | Hemiphroside B is found in Lagotis integra. Hemiphroside B exerts excellent anti-ulcerative colitis effect. | ||||||||||||||||||||
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References
- [1]. Chiu KM, et al. Plantainoside D Reduces Depolarization-Evoked Glutamate Release from Rat Cerebral Cortical Synaptosomes. Molecules. 2023 Jan 30;28(3):1313. [Content Brief]
- [2]. Wang J, et al. Sirt3 regulates NLRP3 and participates in the effects of plantainoside D on acute lung injury sepsis. Aging (Albany NY). 2023 Apr 5;15(14):6710-6720. [Content Brief]
- [3]. Kim DS, et al. Plantainoside D protects adriamycin-induced apoptosis in H9c2 cardiac muscle cells via the inhibition of ROS generation and NF-kappaB activation. Life Sci. 2007 Jan 2;80(4):314-23. [Content Brief]
- [4]. Zhou J, et al. Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity. BMC Complement Med Ther. 2022 Jul 23;22(1):197. [Content Brief]
- [5]. Geng F, Yang L, Chou G, Wang Z. Bioguided isolation of angiotensin-converting enzyme inhibitors from the seeds of Plantago asiatica L. Phytother Res. 2010;24(7):1088-1094. [Content Brief]
- [6]. Zhou P, Hua F, Wang X, Huang JL. Therapeutic potential of IKK-β inhibitors from natural phenolics for inflammation in cardiovascular diseases. Inflammopharmacology. 2020;28(1):19-37. [Content Brief]
