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Results for "

5-HIAA

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15793
    NBI-98782
    1 Publications Verification

    (+)-DTBZ; (+)-α-Dihydrotetrabenazine; (+)-α-DHTBZ

    		 Monoamine Transporter Neurological Disease
    NBI-98782 is a high affinity and selectivity vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki of 3 nM. NBI-98782 has antipsychotic activity .
    NBI-98782
  • HY-23460
    p-Ethynylphenylalanine
    1 Publications Verification

    4-Ethynyl-L-phenylalanine

    		 Tryptophan Hydroxylase Neurological Disease
    p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM . p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    p-Ethynylphenylalanine
  • HY-23460A
    p-Ethynylphenylalanine hydrochloride
    1 Publications Verification

    4-Ethynyl-L-phenylalanine hydrochloride

    		 Tryptophan Hydroxylase Neurological Disease
    p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM . p-Ethynylphenylalanine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    p-Ethynylphenylalanine hydrochloride
  • HY-105542
    Niaprazine

    		Histamine Receptor Neurological Disease
    Niaprazine is a histamine H1-receptor antagonist. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research .
    Niaprazine
  • HY-105542R
    Niaprazine (Standard)

    		Reference Standards Histamine Receptor Neurological Disease
    Niaprazine (Standard) is the analytical standard of Niaprazine. This product is intended for research and analytical applications. Niaprazine is a histamine H1-receptor antagonist. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research .
    Niaprazine (Standard)
  • HY-135242
    LY87130 free base

    		Adrenergic Receptor Endocrinology
    LY87130 free base is an octopamine-N-methyltransferase inhibitor with epinephrine-inhibiting activity. LY87130 free base can significantly reduce the basal level of epinephrine in the hypothalamus after administration. LY87130 free base has no significant effect on the basal levels of norepinephrine, 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in the hypothalamus .
    LY87130 free base
  • HY-129481
    LY 178210

    		5-HT Receptor Neurological Disease
    LY 178210 (Compound 24) is a selective partial agonist of the 5-HT1A receptor, with Ki values ​​of 0.67 and 380 nM for the 5-HT1A and 5-HT1D receptors, respectively. LY 178210 has almost no activity against α₂-adrenergic receptors, 5-HT₂, and other neurotransmitter receptors. LY 178210 inhibits Foscolin-stimulated cyclase activity, but its maximum potency is lower than that of the full agonist 8-OH-DPAT (HY-112061). LY 178210 significantly reduces 5-hydroxyindoleacetic acid (5-HIAA) levels in the greater hypothalamus and increases serum corticosterone concentrations .
    LY 178210
  • HY-182677
    EF-7412

    		5-HT Receptor Dopamine Receptor Neurological Disease
    EF-7412 is a dual antagonist of the 5-HT1A receptor and dopamine D2 receptor, with Ki values of 27 nM and 22 nM, respectively. EF-7412 acts as an antagonist at both pre- and postsynaptic 5-HT1A receptor sites, blocking 8-OH-DPAT (HY-112061)-induced hypothermia, behavioral syndrome, and corticosterone elevation in vivo. EF-7412 increases hypothalamic 5-HIAA/5-HT and DOPAC/DA ratios, alters 5-HT and DA neuronal activity, and slightly decreases spontaneous motor activity. EF-7412 can be used for research on 5-HT1A/D2 receptor regulation and related neural pathways .
    EF-7412

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