114943-19-0
Chemical Structure
LY 178210
- CAS No.: 114943-19-0
- Formula:C18H25N3O
- Molecular Weight:299.41
IUPAC Name: 4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide
InChIKey: YTOJFUORFUYGSV-UHFFFAOYSA-N
SMILES: O=C(C1=C2C3=C(NC=C3CC(N(CCC)CCC)C2)C=C1)N
Biological Activity: LY 178210 (Compound 24) is a selective partial agonist of the 5-HT1A receptor, with Ki values of 0.67 and 380 nM for the 5-HT1A and 5-HT1D receptors, respectively. LY 178210 has almost no activity against α₂-adrenergic receptors, 5-HT₂, and other neurotransmitter receptors. LY 178210 inhibits Foscolin-stimulated cyclase activity, but its maximum potency is lower than that of the full agonist 8-OH-DPAT (HY-112061). LY 178210 significantly reduces 5-hydroxyindoleacetic acid (5-HIAA) levels in the greater hypothalamus and increases serum corticosterone concentrations[1][2].
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LY 178210 | LY 178210 (Compound 24) is a selective partial agonist of the 5-HT1A receptor, with Ki values of 0.67 and 380 nM for the 5-HT1A and 5-HT1D receptors, respectively. LY 178210 has almost no activity against α₂-adrenergic receptors, 5-HT₂, and other neurotransmitter receptors. LY 178210 inhibits Foscolin-stimulated cyclase activity, but its maximum potency is lower than that of the full agonist 8-OH-DPAT (HY-112061). LY 178210 significantly reduces 5-hydroxyindoleacetic acid (5-HIAA) levels in the greater hypothalamus and increases serum corticosterone concentrations. | |||||||||||||||||||||
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References
- [1]. Flaugh ME, et al. 6-substituted 1,3,4,5-tetrahydrobenz[cd]indol-4-amines: potent serotonin agonists. J Med Chem. 1988 Sep;31(9):1746-53. [Content Brief]
- [2]. Slaughter JL, et al. 6-substituted tricyclic partial ergoline compounds are selective and potent 5-hydroxytryptamine1A receptor agents. Life Sci. 1990;47(15):1331-7. [Content Brief]
