525-41-7
Chemical Structure
Harmalan
- CAS No.: 525-41-7
- Formula:C12H12N2
- Molecular Weight:184.24
IUPAC Name: 1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole
InChIKey: CWOYLIJQLSNRRN-UHFFFAOYSA-N
SMILES: CC1=NCCC2=C1NC3=CC=CC=C23
Biological Activity: Harmalan is a tryptamine binding site stimulant and an imidazoline binding site ligand. Harmalan can be isolated from the leaves of Flindersia laevicarpa. Harmalan elevates 5-HT (HY-B1473A) levels and reduces 5-HIAA levels in the cerebral cortex. Harmalan increases spontaneous motor activity, induces clonic convulsions, produces anxiogenic effects, and elicits head weaving, hindlimb abduction, trunk curvature, piloerection, resting tremor, ataxia, forelimb abduction with increased muscle tone, and occasional alternating forepaw treading behaviors[1][2][3].
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Harmalan | Harmalan is a tryptamine binding site stimulant and an imidazoline binding site ligand. Harmalan can be isolated from the leaves of Flindersia laevicarpa. Harmalan elevates 5-HT (HY-B1473A) levels and reduces 5-HIAA levels in the cerebral cortex. Harmalan increases spontaneous motor activity, induces clonic convulsions, produces anxiogenic effects, and elicits head weaving, hindlimb abduction, trunk curvature, piloerection, resting tremor, ataxia, forelimb abduction with increased muscle tone, and occasional alternating forepaw treading behaviors. | |||||||||||||||||||||
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- [1]. Rommelspacher H, et al. Pharmacology of harmalan (1-methyl-3,4-dihydro-beta-carboline). European journal of pharmacology. 1985 Mar 12;109(3):363-71.
- [2]. Picker K, et al. The chemical constituents of Australian Flindersia species. XXI. An examination of the bark and the leaves of F. laevicarpa[J]. Australian Journal of Chemistry, 1976, 29(9): 2023-2036.
- [3]. Parker CA, et al. Harmane and harmalan are bioactive components of classical clonidine-displacing substance. Biochemistry. 2004 Dec 28;43(51):16385-92.
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