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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
ATPase assay
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "ATPase assay" in MCE Product Catalog:
6
1
GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK .
Cat. No.: HY-174374
CAS No.: 3076446-44-8
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Topobexin is a TOP2B-selective inhibitor with IC50 values of 0.19 μM and 4.8 μM for TOP2B and TOP2A (DNA decatenation assay). Topobexin binds to non-homologous residues in the obex pocket and targets the ATPase domain of TOP2B. Topobexin prevents anthracycline-induced DNA double-strand break formation, apoptotic signaling mediated by caspase 3/7, 8 and 9, cardiomyocyte morphological changes, mitochondrial depolarization/loss, left ventricular systolic dysfunction, extracellular matrix remodeling, fibrotic alterations, and increases in plasma cardiac troponin T and BNP. Topobexin does not impair the antiproliferative effects of anthracyclines in cancer cells, exhibits no intrinsic cytotoxicity in cardiomyocytes, and is well tolerated in rabbits. Topobexin can be used in studies related to anthracycline-induced cardiotoxicity .
Cat. No.: HY-33838
CAS No.: 18474-59-4
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eIF4A3-IN-8 serves as a negative control targeting eukaryotic initiation factor 4A3 (eIF4A3), with an IC50 > 100 μM; it exhibits no significant activity .
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ATPase-IN-4 (Compound MS1) inhibits the ATPase activity of EHD4 (IC50: 0.92 μM). ATPase-IN-4 also inhibits EHD2 enzymatic activity
Cat. No.: HY-W107935
CAS No.: 1383133-23-0
Hsp90-IN-37 (Z-2) is a heat shock protein 90 (Hsp90) inhibitor that inhibits Hsp90 enzymatic activity by 69%. Hsp90-IN-37 has antitumor activity .
Cat. No.: HY-D1560
CAS No.: 438476-80-3
Cat. No.: HY-185458
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DHX8-IN-1 is a DHX8 inhibitor with an IC50 of 40 nM in ATPase activity assays. DHX8-IN-1 can be used in research on DHX8-related diseases such as Dupuytren's contracture and HIV-1 infection .
Cat. No.: HY-W1143950
CAS No.: 25840-83-9
O-Trityl-L-serine is an inhibitor of human mitotic kinesin Eg5, with a Ki app of 750 nM. O-Trityl-L-serine does not induce monopolar spindle formation or mitotic arrest in cancer cells. O-Trityl-L-serine can be used in cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
