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Cat. No.: HY-W1143950

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O-Trityl-L-serine

O-Trityl-L-serine is an inhibitor of human mitotic kinesin Eg5, with a K_i^app of 750 nM. O-Trityl-L-serine does not induce monopolar spindle formation or mitotic arrest in cancer cells. O-Trityl-L-serine can be used in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 25840-83-9
Formula: C₂₂H₂₁NO₃
Molecular Weight:347.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

O-Trityl-L-serine Chemical Structure

CAS No.: 25840-83-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

IC₅₀ & Target

^[1]

Eg5

750 nM (Ki app)

All Kinesin Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	5 μM Compound: 34	Induction of mitotic arrest in human HeLa cells assessed as monoastral spindle formation after 24 hrs Induction of mitotic arrest in human HeLa cells assessed as monoastral spindle formation after 24 hrs	[PMID: 18266314]

In Vitro

O-Trityl-L-serine (compound 34) inhibits the basal ATPase activity of human mitotic kinesin Eg5 in cell-free assays, with an apparent inhibition constant K_i^app of 750 nM^[1].
O-Trityl-L-serine (5 μM; 8 h) does not induce mitotic arrest or monopolar spindle formation in HeLa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 25840-83-9
Molecular Weight 347.41
Formula C₂₂H₂₁NO₃
SMILES

C(OC[C@@H](C(O)=O)N)(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Debonis S, et al. Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5. Journal of medicinal chemistry. 2008 Mar 13;51(5):1115-25. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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