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Albaconol

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N20661
    Albaconol

    		Endogenous Metabolite NF-κB Topoisomerase Apoptosis IKK NO Synthase MHC TRP Channel Neurological Disease Inflammation/Immunology Cancer
    Albaconol is a prenylresorcinol compound. Albaconol is isolated from the mushroom A. confluens. Albaconol inhibits NF-κB and DNA topoisomerase II, and induces Apoptosis. Albaconol inhibits IκB-α phosphorylation and p65 nuclear translocation, enhances SOCS1 expression, reduces the production of proinflammatory cytokines and NO, and suppresses the expression of iNOS, MHC-II and co-stimulatory molecules. Albaconol acts as a weak antagonist of hVR1 and rVR1, with IC50 values of 17 µM and 5.5 µM, respectively. Albaconol induces tracheal contraction and desensitization. Albaconol inhibits the growth of tumor cells. Albaconol can be used in pain-related research .
    Albaconol

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