338405-64-4
Chemical Structure
Albaconol
- CAS No.: 338405-64-4
- Formula:C22H34O3
- Molecular Weight:346.50
InChIKey: APLGGFLATUGFCO-YUVXSKOASA-N
SMILES: C[C@@]12[C@H]([C@](O)(CC[C@@]1([H])C(C)(CCC2)C)C)CC3=C(C=C(C=C3O)C)O
Biological Activity: Albaconol is a prenylresorcinol compound. Albaconol is isolated from the mushroom A. confluens. Albaconol inhibits NF-κB and DNA topoisomerase II, and induces Apoptosis. Albaconol inhibits IκB-α phosphorylation and p65 nuclear translocation, enhances SOCS1 expression, reduces the production of proinflammatory cytokines and NO, and suppresses the expression of iNOS, MHC-II and co-stimulatory molecules. Albaconol acts as a weak antagonist of hVR1 and rVR1, with IC50 values of 17 µM and 5.5 µM, respectively. Albaconol induces tracheal contraction and desensitization. Albaconol inhibits the growth of tumor cells. Albaconol can be used in pain-related research[1][2][3][4].
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Albaconol | Albaconol is a prenylresorcinol compound. Albaconol is isolated from the mushroom A. confluens. Albaconol inhibits NF-κB and DNA topoisomerase II, and induces Apoptosis. Albaconol inhibits IκB-α phosphorylation and p65 nuclear translocation, enhances SOCS1 expression, reduces the production of proinflammatory cytokines and NO, and suppresses the expression of iNOS, MHC-II and co-stimulatory molecules. Albaconol acts as a weak antagonist of hVR1 and rVR1, with IC50 values of 17 µM and 5.5 µM, respectively. Albaconol induces tracheal contraction and desensitization. Albaconol inhibits the growth of tumor cells. Albaconol can be used in pain-related research. | |||||||||||||||||||||
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- [1]. Liu Q, et al. Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappaB activation and enhancing SOCS1 expression. Cellular & molecular immunology. 2008 Aug;5(4):271-8. [Content Brief]
- [2]. Liu Q, et al. Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappaB activation. International immunopharmacology. 2008 Aug;8(8):1103-11. [Content Brief]
- [3]. Hellwig V, et al. Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product, confluentin. Archiv der Pharmazie. 2003 Apr;336(2):119-26. [Content Brief]
- [4]. Zhi‐Hui D, et al. Albaconol, A Novel Prenylated Resorcinol (= Benzene‐1, 3‐diol) from Basidiomycetes Albatrellus confluens[J]. Helvetica Chimica Acta, 2001, 84(1): 259-262.
Keywords
