2. Metabolic Enzyme/Protease NF-κB Cell Cycle/DNA Damage Apoptosis Immunology/Inflammation Neuronal Signaling Membrane Transporter/Ion Channel
  3. Endogenous Metabolite NF-κB Topoisomerase Apoptosis IKK NO Synthase MHC TRP Channel
  4. Albaconol

Albaconol is a prenylresorcinol compound. Albaconol is isolated from the mushroom A. confluens. Albaconol inhibits NF-κB and DNA topoisomerase II, and induces Apoptosis. Albaconol inhibits IκB-α phosphorylation and p65 nuclear translocation, enhances SOCS1 expression, reduces the production of proinflammatory cytokines and NO, and suppresses the expression of iNOS, MHC-II and co-stimulatory molecules. Albaconol acts as a weak antagonist of hVR1 and rVR1, with IC50 values of 17 µM and 5.5 µM, respectively. Albaconol induces tracheal contraction and desensitization. Albaconol inhibits the growth of tumor cells. Albaconol can be used in pain-related research.

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Albaconol

Albaconol Chemical Structure

CAS No. : 338405-64-4

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Albaconol Related Antibodies

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Human Endogenous Metabolite Microbial Metabolite

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Topoisomerase Topo I Topo II DNA gyrase

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IKK-α IKK-β IKK IKKε TBK1

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nNOS iNOS eNOS

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MHC I MHC II

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TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

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Description

Albaconol is a prenylresorcinol compound. Albaconol is isolated from the mushroom A. confluens. Albaconol inhibits NF-κB and DNA topoisomerase II, and induces Apoptosis. Albaconol inhibits IκB-α phosphorylation and p65 nuclear translocation, enhances SOCS1 expression, reduces the production of proinflammatory cytokines and NO, and suppresses the expression of iNOS, MHC-II and co-stimulatory molecules. Albaconol acts as a weak antagonist of hVR1 and rVR1, with IC50 values of 17 µM and 5.5 µM, respectively. Albaconol induces tracheal contraction and desensitization. Albaconol inhibits the growth of tumor cells. Albaconol can be used in pain-related research[1][2][3][4].

IC50 & Target[2][1]

Fungal Metabolite

 

Topoisomerase II

 

iNOS

 

MHC II

 

In Vitro

Albaconol (0.5-20 μg/mL; 8-53 h) inhibits proliferation of RAW264.7 cells in a dose- and time-dependent manner with an IC50 of 5.55 μg/mL[1].
Albaconol (2.5-7.5 μg/mL; 24 h) at 7.5 μg/mL induces apoptosis of RAW264.7 cells, while concentrations of 2.5 μg/mL and 5.0 μg/mL do not cause significant apoptosis[1].
Albaconol (5.0 μg/mL; 24 h pretreatment, followed by 24 h LPS stimulation) inhibits TNF-α, IL-1β, and IL-6 mRNA expression in both unstimulated and LPS-stimulated RAW264.7 cells[1].
Albaconol (2.5-5.0 μg/mL; 24 h pretreatment, followed by 24 h LPS stimulation) at 5.0 μg/mL inhibits LPS-induced TNF-α, IL-1β, and IL-6 production in RAW264.7 cells, while 2.5 μg/mL albaconol only inhibits LPS-induced IL-1β production[1].
Albaconol (2.5-5.0 μg/mL; 24 h pretreatment, followed by 12-24 h LPS stimulation) at 5.0 μg/mL inhibits LPS-induced iNOS expression and NO production in RAW264.7 cells, while 2.5 μg/mL albaconol has no effect on these endpoints[1].
Albaconol (2.5-50 μg/mL; 24 h) at concentrations ≤10 μg/mL does not induce apoptosis/necrosis in mouse bone marrow-derived CD11c+ dendritic cells, while higher concentrations (20 μg/mL, 50 μg/mL) do trigger apoptotic/necrotic cell death[2].
Albaconol (3.0 μg/mL; 12 h pretreatment, 24 h LPS stimulation) inhibits LPS-induced upregulation of MHC-II (Ia), CD40, CD80, and CD86 expression in mouse bone marrow-derived CD11c+ dendritic cells[2].
Albaconol (up to 50 µM) exhibits no agonistic activity on hVR1-expressing recombinant CHO cells at concentrations up to 50 µM[3].
Albaconol acts as a weak antagonist of hVR1 in hVR1-expressing recombinant CHO cells, with an IC50 of 17 µM[3].
Albaconol acts as a weak antagonist of rVR1, with an IC50 of 5.5 µM, and exhibits no agonistic activity on rVR1[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Albaconol Related Antibodies

Cell Proliferation Assay[1]

Cell Line: RAW264.7
Concentration: 0.5-20 μg/mL
Incubation Time: 8-53 h
Result: Inhibited RAW264.7 cell proliferation in a dose- and time-dependent manner.
Achieved an IC50 value of 5.55 μg/mL.
Induced obvious proliferation inhibition after 24 hours of treatment with 2.5 μg/mL or 5.0 μg/mL.
Maintained inhibitory effect from 24 h to 47 h.

Apoptosis Analysis[1]

Cell Line: RAW264.7
Concentration: 2.5-7.5 μg/mL
Incubation Time: 24 h
Result: Induced significant apoptosis of RAW264.7 cells at 7.5 μg/mL.
Showed no obvious proapoptotic activity at 2.5 μg/mL or 5.0 μg/mL.

Real Time qPCR[1]

Cell Line: RAW264.7
Concentration: 5.0 μg/mL
Incubation Time: 24 h pretreatment, followed by 24 h LPS stimulation
Result: Significantly inhibited mRNA expression of TNF-α, IL-1β, and IL-6 in both unstimulated and LPS-stimulated RAW264.7 cells.

Western Blot Analysis[1]

Cell Line: RAW264.7
Concentration: 2.5-5.0 μg/mL
Incubation Time: 24 h pretreatment, followed by 12-24 h LPS stimulation
Result: Markedly inhibited LPS-induced iNOS mRNA and protein expression, as well as LPS-induced NO production at 5.0 μg/mL.
Showed no inhibitory effect on LPS-induced iNOS expression or NO production at 2.5 μg/mL.
In Vivo

Albaconol (when DCs treated with Albaconol are transplanted in vivo) inhibits the ability of dendritic cells (DCs) to initiate ovalbumin (OVA)-specific CD4+ T cell proliferation in mice, reducing the proportion of antigen-specific CD4+ T cells from 9.8% to 0.5%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: F1 (BALB/c × C57BL/6)[2]
Dosage: DC pretreatment
Administration: in vitro pretreatment; 12 hours prior to LPS stimulation
Result: Reduced the percentage of OVA-specific KJ1-26+ CD4+ T cells from 9.8% to 0.5%.
Molecular Weight

346.50

Formula

C22H34O3
CAS No.
SMILES

C[C@@]12[C@H]([C@](O)(CC[C@@]1([H])C(C)(CCC2)C)C)CC3=C(C=C(C=C3O)C)O
Structure Classification
Initial Source

Albatrellus spp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Albaconol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Albaconol338405-64-4Endogenous MetaboliteNF-κBTopoisomeraseApoptosisIKKNO SynthaseMHCTRP ChannelNuclear factor-κBNuclear factor-kappaBIκB kinaseI kappa B kinase Nitric oxide synthasesNOSMajor Histocompatibility ComplexTransient receptor potential channelsOVA-specific CD4+ T cellmouse bone marrow-derived CD11c+ dendritic cellsRAW264.7 cellsDNA topoisomerase IIhVR1IκB-αT cellsSOCS1rVR1Inhibitorinhibitorinhibit

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