1 Result for "

BRD3308

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "BRD3308" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-19618
CAS No.: 1550053-02-5
Target:  

HDAC HIV Apoptosis

Research Areas:  

Infection Metabolic Disease

BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC50 of 1.26 μM) or HDAC2 (IC50 of 1.34 μM). BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release. BRD3308 activates HIV-1 transcription and disrupts HIV-1 latency .
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